Umbilical cord blood hematopoietic stem and repopulating cells in human clinical transplantation.
Umbilical cord blood hematopoietic stem and repopulating cells in human clinical transplantation.
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发表时间：
1991
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通讯作者：
H. Broxmeyer;J. Kurtzberg;E. Gluckman;A. Auerbach;G. Douglas;S. Cooper;J. Falkenburg;J. Bard;E. A. Boyse
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作者：
H. Broxmeyer;J. Kurtzberg;E. Gluckman;A. Auerbach;G. Douglas;S. Cooper;J. Falkenburg;J. Bard;E. A. Boyse
本文回顾了我们最近的实验室和临床研究，证明了人类脐带血在治疗Fanconi‘s贫血的病例中有效地使用了人类白细胞抗原相合的异基因同胞干细胞/祖细胞移植。讨论了以下方面的未来影响和潜在问题：(A)母体细胞污染的可能性；(B)适用于其他可能移植的疾病的广泛性；这种移植在成人和儿童中是否可行；(C)脐带血细胞的免疫反应性，以及这些细胞是否比成人骨髓更容易用于跨越组织相容性障碍。
This paper reviews our recent laboratory and clinical studies demonstrating the efficacious use of human umbilical cord blood for HLA-matched allogeneic sibling stem/progenitor cell transplantation in cases of Fanconi's anemia. Future implications and potential problems are discussed with regards to (a) the possibility of maternal cell contamination, (b) the broadness of applicability with regards to other diseases that might be transplanted, and whether such transplants are feasible in adults, as well as in children, and (c) the immunological reactivity of cord blood cells, and whether these cells can be used to cross histocompatibility barriers more easily than that of bone marrow from adults.