Scarless fetal wound healing: a basic science review.
Scarless fetal wound healing: a basic science review.
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无疤痕胎儿伤口愈合：基础科学评论。
DOI：
10.1097/prs.0b013e3181eae781
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发表时间：
2010-10
影响因子：
3.6
通讯作者：
Lorenz HP
中科院分区：
文献类型：
--
作者：
Larson BJ;Longaker MT;Lorenz HP
疤痕形成是一个主要的医疗问题，可能会对患者造成毁灭性的后果。疤痕的不良生理和心理影响是广泛的，目前没有可靠的治疗方法来防止疤痕。与成人伤口相反，妊娠早期胎儿皮肤伤口修复迅速，并且没有瘢痕形成。尽管进行了广泛的研究，但胎儿伤口无瘢痕愈合的确切机制仍不清楚。一段时间以来，已经知道胎儿和出生后伤口的细胞外基质、炎症反应、细胞介质和基因表达谱之间存在显著差异。这些差异可能在无瘢痕伤口修复中具有重要意义。
Scar formation is a major medical problem that can have devastating consequences for patients. The adverse physiological and psychological effects of scars are broad, and there are currently no reliable treatments to prevent scarring. In contrast to adult wounds, early gestation fetal skin wounds repair rapidly and in the absence of scar formation. Despite extensive investigation, the exact mechanisms of scarless fetal wound healing remain largely unknown. For some time, it has been known that significant differences exist among the extracellular matrix, inflammatory response, cellular mediators, and gene expression profiles of fetal and postnatal wounds. These differences may have important implications in scarless wound repair.