Orientation and mobility assessment in retinal prosthetic clinical trials.
Orientation and mobility assessment in retinal prosthetic clinical trials.
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DOI：
10.1097/opx.0b013e3182686251
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发表时间：
2012-09
期刊：
影响因子：
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通讯作者：
Dagnelie G
中科院分区：
文献类型：
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作者：
Geruschat DR;Bittner AK;Dagnelie G
目的：本研究的目的是制定一个定向和移动性（O&M）评估协议，实施于植入人工硅视网膜（ASR）的受试者，并利用这一经验提出一个研究议程，O&M与假肢vision. Methods。一个控制和自然主义的评估，包括步行规定的障碍课程和往返医院食堂。受试者在植入ASR之前以及植入后3个月和6个月接受了测试。结果测量为步行速度和与障碍物接触的次数。本研究的经验，导致了一个建议的研究议程，在O&M。结果。八个主题与视网膜色素变性参与了这项研究。受试者的视力状态范围为< 20/1600至20/80的视力和< 5至40的视野。使用重复测量方差分析，在主要结果测量中没有发现差异。观察到4例受试者在植入后活动度降低。三名受试者自我报告增强植入后的旅行，但这种增强是没有observed.Conclusions。这项研究表明，流动性可能不会得到改善与假肢的视力。拟议的研究议程强调了发展个性化评估的重要性，确定具体的项目的方向，而不是流动性测量假肢视力的影响，并制定和评估可能需要获得的技术的全部好处的教学计划。
Purpose.The purpose of this study was to develop an orientation and mobility (O&M) assessment protocol to implement in subjects who have been implanted with an artificial silicon retina (ASR), and to use this experience to propose a research agenda for O&M with prosthetic vision.Methods.A controlled and naturalistic assessment was developed that included walking a prescribed obstacle course and travel to and from a hospital cafeteria. Subjects were tested before and 3 and 6 months after being implanted with the ASR. Outcome measures were walking speed and number of contacts with obstacles. The experiences from this study led to a proposed research agenda in O&M.Results.Eight subjects with retinitis pigmentosa participated in this study. The vision status of the subjects ranged from< 20/1600 to 20/80 visual acuity and visual fields of< 5 to 40. Using a repeated-measures analysis of variance, no differences were found in the primary outcome measures. Four subjects were observed to have reduced mobility after implantation. Three subjects self-reported enhancements of travel after implantation, but this enhancement was not observed.Conclusions.This study demonstrates that mobility might not be improved with prosthetic vision. The proposed research agenda emphasizes the importance of developing individualized assessments, identifying specific items of orientation rather than mobility for measuring the effect of prosthetic vision, and to develop and evaluate instructional programs that may be needed to obtain the full benefit of the technology.