Carbon fiber-based multichannel solid-contact potentiometric ion sensors for real-time sweat electrolyte monitoring.
Carbon fiber-based multichannel solid-contact potentiometric ion sensors for real-time sweat electrolyte monitoring.
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DOI：
10.1016/j.aca.2023.342046
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发表时间：
2023-11
影响因子：
6.2
通讯作者：
Meixue Lai;Lijie Zhong;Siyi Liu;Yitian Tang;Tingting Han;Huali Deng;Y. Bao;Yingming Ma;Wei Wang;Li Niu;Shiyu Gan
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文献类型：
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作者：
Meixue Lai;Lijie Zhong;Siyi Liu;Yitian Tang;Tingting Han;Huali Deng;Y. Bao;Yingming Ma;Wei Wang;Li Niu;Shiyu Gan
固体接触离子选择电极(SC-ISES)具有小型化和集成化的特点，在非侵入式可穿戴汗液电解质传感器中得到了广泛的关注。目前最先进的可穿戴SC-ISES主要使用聚对苯二甲酸乙二酯、金和碳纳米管纤维作为柔性基材，但存在舒适性差、成本高和生物毒性等问题。在这里，我们报道了基于碳纤维的SC-ISES构建了一种用于汗液电解质监测(Na+/K+/pH/Cl−)的四通道可穿戴电位传感器。碳纤维是从商业布料中提取出来的，其出发点是解决柔性SC-ISE的成本和重复性问题。裸碳纤维电极具有可逆的伏安性能和稳定的阻抗性能。进一步制备的基于相应离子选择膜的SC-ISES对汗液中的离子和有机物种都具有能斯特敏感性和反界面能力。值得注意的是，这些基于碳纤维的SC-ISE显示出在正常和弯曲状态之间标准电位的高度重现性。最后，将基于织物的传感器与固体接触参比电极集成，实现了体内汗液电解质的分析。与离子色谱柱外检测结果相比，结果具有较高的准确度。这项工作突出了基于碳纤维的多通道可穿戴电位型离子传感器具有低成本、生物兼容性和重复性。
Solid-contact ion-selective electrodes (SC-ISEs) feature miniaturization and integration that have gained extensive attention in non-invasive wearable sweat electrolyte sensors. The state-of-the-art wearable SC-ISEs mainly use polyethylene terephthalate, gold and carbon nanotube fibers as flexible substrates but suffer from uncomfortableness, high cost and biotoxicity. Herein, we report carbon fiber-based SC-ISEs to construct a four-channel wearable potentiometric sensor for sweat electrolytes monitoring (Na+/K+/pH/Cl−). The carbon fibers were extracted from commercial cloth, of which the starting point is addressing the cost and reproducibility issues for flexible SC-ISEs. The bare carbon fiber electrodes exhibited reversible voltammetric and stable impedance performances. Further fabricated SC-ISEs based on corresponding ion-selective membranes disclosed Nernstian sensitivity and anti-interface ability toward both ions and organic species in sweat. Significantly, these carbon fiber-based SC-ISEs revealed high reproducibility of standard potentials between normal and bending states. Finally, a textile-based sensor was integrated with a solid-contact reference electrode, which realized on-body sweat electrolytes analysis. The results displayed high accuracy compared with ex-situ tests by ion chromatography. This work highlights carbon fiber-based multichannel wearable potentiometric ion sensors with low cost, biocompatibility and reproducibility.