Amelioration of negative symptoms in schizophrenia by glycine.
Amelioration of negative symptoms in schizophrenia by glycine.
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DOI：
10.1176/ajp.151.8.1234
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发表时间：
1994-08
期刊：
影响因子：
--
通讯作者：
Daniel C. Javitt;I. Zylberman;Stephen R. Zukin;U. Heresco-Levy;J. Lindenmayer
中科院分区：
文献类型：
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作者：
Daniel C. Javitt;I. Zylberman;Stephen R. Zukin;U. Heresco-Levy;J. Lindenmayer
苯环利定通过阻断N-甲基-D-天冬氨酸（NMDA）受体的神经传递诱导拟精神病状态。在一个双盲，安慰剂对照的方式，14例慢性精神分裂症的药物治疗与甘氨酸，NMDA受体介导的神经传递的增效剂。阴性症状的显著改善发生在给予甘氨酸的组中，但在给予安慰剂的组中没有，这表明NMDA受体介导的神经传递的增强可能代表精神分裂症中抗精神病药耐药阴性症状的有效治疗。
Phencyclidine induces a psychotomimetic state by blocking neurotransmission at N-methyl-D-aspartic acid (NMDA) receptors. In a double-blind, placebo-controlled fashion, 14 medicated patients with chronic schizophrenia were treated with glycine, a potentiator of NMDA-receptor-mediated neurotransmission. Significant improvement in negative symptoms occurred in the group given glycine but not in the group given placebo, suggesting that potentiation of NMDA-receptor-mediated neurotransmission may represent an effective treatment for neuroleptic-resistant negative symptoms in schizophrenia.