Quantification of speech and synchrony in the conversation of adults with autism spectrum disorder
Quantification of speech and synchrony in the conversation of adults with autism spectrum disorder
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DOI：
10.1371/journal.pone.0225377
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发表时间：
2019-12-05
期刊：
影响因子：
3.7
通讯作者：
Yamasue, Hidenori
中科院分区：
文献类型：
--
作者：
Ochi, Keiko;Ono, Nobutaka;Yamasue, Hidenori
自闭症谱系障碍（ASD）是一种高度流行的神经发育障碍，其特征是社会互惠和沟通障碍以及兴趣受限和刻板行为。自闭症诊断观察表（ADOS）被认为是ASD诊断的“金标准”工具，主要取决于训练有素的临床医生的主观评估。为了开发ASD症状的定量和客观的替代标记，我们研究了语音特征，包括F-0，语速，说话时间和话轮转换间隙，从ADOS的半结构化社交互动情况下记录的镜头中提取。我们不仅计算了整个ADOS活动的统计值，而且还进行了块分析，计算了每个8 s滑动窗口中韵律特征的统计值。块分析确定了参与者是否根据对话的流程改变了音量或音调。我们还测量了参与者和ADOS管理员之间的同步性。与典型发育（TD）的参与者相比，高功能ASD的参与者表现出明显更长的话轮转换间隙和更大比例的停顿时间，更少的变异性和更少的块平均强度同步变化（p
Autism spectrum disorder (ASD) is a highly prevalent neurodevelopmental disorder characterized by impairments in social reciprocity and communication together with restricted interest and stereotyped behaviors. The Autism Diagnostic Observation Schedule (ADOS) is considered a 'gold standard' instrument for diagnosis of ASD and mainly depends on subjective assessments made by trained clinicians. To develop a quantitative and objective surrogate marker for ASD symptoms, we investigated speech features including F-0, speech rate, speaking time, and turn-taking gaps, extracted from footage recorded during a semi-structured socially interactive situation from ADOS. We calculated not only the statistic values in a whole session of the ADOS activity but also conducted a block analysis, computing the statistical values of the prosodic features in each 8s sliding window. The block analysis identified whether participants changed volume or pitch according to the flow of the conversation. We also measured the synchrony between the participant and the ADOS administrator. Participants with high-functioning ASD showed significantly longer turn-taking gaps and a greater proportion of pause time, less variability and less synchronous changes in blockwise mean of intensity compared with those with typical development (TD) (p