A controlled trial of daily left prefrontal cortex TMS for treating depression
A controlled trial of daily left prefrontal cortex TMS for treating depression
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DOI：
10.1016/s0006-3223(00)01048-9
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发表时间：
2000-11-15
影响因子：
10.6
通讯作者：
Ballenger, JC
中科院分区：
文献类型：
--
作者：
George, MS;Nahas, Z;Ballenger, JC
背景：经颅磁刺激（TMS）是一种无创刺激大脑的新技术，一些研究表明，每天用TMS刺激左前额叶皮层2周可能具有抗抑郁作用。我们进行了一项平行设计、双掩蔽、假对照的研究，以确定两周的每日经颅磁刺激对左前额叶皮层的抗抑郁活性是否比假治疗更强。方法：30例非精神病性、重度抑郁（n = 21）或双相（n = 9）（抑郁期）障碍的成人门诊患者，均为当前重度抑郁（汉密尔顿抑郁量表[HRSD] 21项评分>18），每个工作日治疗2周。受试者被随机分配接受每日活动刺激（20名受试者）或假刺激（10名受试者）。此外，20名活跃的受试者被平均分为慢（5赫兹）和快（20赫兹）频率治疗。抗抑郁反应被定义为基线HRSD改善大于50%，结果：激活TMS导致应答者（9/20）明显多于假组（0/10）（chi (2) = 6.42, p < 0.01），两种激活细胞之间应答者数量无显著差异（3/10快，6/10慢）。从基线变化的百分比来看，活跃的经颅刺激受试者在贝克抑郁量表和汉密尔顿焦虑评定量表上比接受假刺激的受试者有显著更大的改善。结论：每日左前额叶经颅磁刺激治疗2周显著减轻抑郁症状大于假治疗，两种形式的主动经颅磁刺激治疗没有显著差异，(C) 2000社会生物精神病学。
Background: Transcranial magnetic stimulation (TMS) is a new technology for noninvasively stimulating the brain, Several studies have suggested that daily stimulation of the left prefrontal cortex with TMS for 2 weeks has probable antidepressant effects. We conducted a parallel-design, double-masked, sham-controlled study to address whether 2 weeks of daily TMS over the left prefrontal cortex has antidepressant activity greater than sham.Methods: Thirty medication-free adult outpatients with nonpsychotic, major depressive (n = 21) or bipolar (n = 9) (depressed phase) disorder who were in a current major depression (Hamilton Rating Scale for Depression [HRSD] 21-item score of >18) were treated each weekday for 2 weeks. Subjects were randomly assigned to receive either daily active (20 subjects) or sham (10 subjects) stimulation. Additionally, the 20 active subjects I were equally divided between slower (5 Hz) andfaster (20 Hz) frequency treatment. Antidepressant response was defined as greater than a 50% improvement in the baseline HRSD,Results: Active TMS resulted in significantly more responders (9/20) than did sham (0/10) (chi (2) = 6.42, p < .01), The number of responders did not differ significantly between the two active cells (3/10 faster and 6/10 slower). Expressed as a percent change from baseline, active TMS subjects had significantly greater improvement on the Beck Depression Inventory as well as the Hamilton Anxiety Rating Scale than did those who received sham.Conclusions: Daily left prefrontal TMS for 2 weeks significantly reduced depression symptoms greater than did sham, The two forms of active TMS treatment did not differ significantly, (C) 2000 Society of Biological Psychiatry.