Uniform double-walled polymer microspheres of controllable shell thickness
Uniform double-walled polymer microspheres of controllable shell thickness
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DOI：
10.1016/j.jconrel.2004.01.018
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发表时间：
2004-04-16
影响因子：
10.8
通讯作者：
Kim, K
中科院分区：
文献类型：
--
作者：
Berkland, C;Pollauf, E;Kim, K
开发了一种制造尺寸和壳厚度可控的均匀双壁微球的方法。该方法基于先前制造均匀微球的工作，采用多个同心喷嘴产生包含环形壳和芯材料的平滑同轴射流，该射流被声学激励分解成均匀的核-壳液滴。控制射流的方向、材料流速和溶剂萃取速率，以产生均匀且居中的“双壁”微球，并表现出可控的壳厚度。双壁微球由不同排列的本体侵蚀聚(D,L-丙交酯-乙交酯) (PLG) 和表面侵蚀聚[(1,6-双羧基苯氧基)己烷] (PCPH) 制成。制造参数的变化允许壳相完全封装，包括有效形成封装 PLG 核的 PCPH 壳。利用这项技术，双壁微球壳的厚度可以从<2μm到数十微米不等，同时保持总直径接近50μm的双壁微球完整且居中的核心封装。 (C) 2004 Elsevier B.V. 保留所有权利。
A method for fabricating uniform double-walled microspheres with controllable size and shell thickness has been developed. The method, based on previous work to fabricate uniform microspheres, employs multiple concentric nozzles to produce a smooth coaxial jet comprising an annular shell and core material, which is acoustically excited to break up into uniform core-shell droplets. The orientation of the jets, material flow rates, and rate of solvent extraction are controlled to create uniform and well-centered "double-walled" microspheres exhibiting a controllable shell thickness. Double-walled microspheres were fabricated with different arrangements of bulk-eroding poly(D,L-lactide-co-glycolide) (PLG) and surface-eroding poly[(1,6-bis-carboxyphenoxy) hexane] (PCPH). Variation of the fabrication parameters allowed complete encapsulation by the shell phase, including the efficient formation of a PCPH shell encapsulating a PLG core. Utilizing this technology, double-walled microsphere shell thickness can be varied from < 2 mum to tens of microns while maintaining complete and well-centered core encapsulation for double-walled microspheres near 50 mum in overall diameter. (C) 2004 Elsevier B.V. All rights reserved.