No evidence for clonal transmission of urogenital carcinoma in California sea lions ( Zalophus californianus).
No evidence for clonal transmission of urogenital carcinoma in California sea lions ( Zalophus californianus).
复制标题
DOI：
10.12688/wellcomeopenres.11483.1
复制
发表时间：
2017
影响因子：
--
通讯作者：
Murchison EP
中科院分区：
文献类型：
--
作者：
Ní Leathlobhair M;Gulland FMD;Murchison EP
泌尿生殖道癌是一种影响加州海狮（Zalophus californianus）的高度转移性癌症。这种疾病在搁浅动物中的发病率很高，是野生动物中最常见的癌症之一。原发性肿瘤的生殖器定位表明，性交传播的感染因子可能是这种疾病的基础。1型卵巢疱疹病毒与病变有关，但这种病毒的致病作用尚未得到证实。我们研究了泌尿生殖道癌可能是克隆传播的可能性，通过癌细胞的直接转移而传播。在7个匹配的肿瘤和宿主对的线粒体DNA控制区的序列分析证实，肿瘤基因型与其匹配的宿主相同，并没有显示出与其他个体的肿瘤相似。因此，我们的研究结果表明，泌尿生殖系统癌在加州海狮是不是克隆传播，而是来自转化宿主细胞。
Urogenital carcinoma is a highly metastatic cancer affecting California sea lions ( Zalophus californianus). The disease has high prevalence amongst stranded animals, and is one of the most commonly observed cancers in wildlife. The genital localisation of primary tumours suggests the possibility that coital transmission of an infectious agent could underlie this disease. Otarine herpesvirus type 1 has been associated with lesions, however a causative role for this virus has not been confirmed. We investigated the possibility that urogenital carcinoma might be clonally transmissible, spread by the direct transfer of cancer cells. Analysis of sequences at the mitochondrial DNA control region in seven matched tumour and host pairs confirmed that tumour genotypes were identical to those of their matched hosts and did not show similarity with tumours from other individuals. Thus our findings suggest that urogenital carcinoma in California sea lions is not clonally transmitted, but rather arises from transformed host cells.