Dual-responsive nanoparticles release cargo upon exposure to matrix metalloproteinase and reactive oxygen species.
Dual-responsive nanoparticles release cargo upon exposure to matrix metalloproteinase and reactive oxygen species.
复制标题
DOI：
10.1039/c5cc09164k
复制
发表时间：
2016-02-04
期刊：
影响因子：
--
通讯作者：
Cohen SM
中科院分区：
文献类型：
--
作者：
Daniel KB;Callmann CE;Gianneschi NC;Cohen SM
胶束纳米粒子被设计为对基质金属蛋白酶（MMP）和活性氧（ROS）有反应，这两种酶在炎症性疾病的病理学中都会上调。基于两亲性聚合物的纳米粒子系统由负责粒子形态变化和聚集的亲水性外壳以及设计用于在存在ROS的情况下释放货物的疏水性嵌段组成。
Micellar nanoparticles were designed to be responsive to matrix metalloproteinases (MMPs) and reactive oxygen species (ROS), each of which is upregulated in the pathology of inflammatory diseases. The amphiphilic polymer-based nanoparticle system consists of a hydrophilic shell responsible for particle morphology change and aggregation, together with a hydrophobic block designed to release cargo in the presence of ROS.