EPILEPSY DUE TO NEUROCYSTICERCOSIS - ANALYSIS OF 203 PATIENTS
EPILEPSY DUE TO NEUROCYSTICERCOSIS - ANALYSIS OF 203 PATIENTS
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DOI：
10.1212/wnl.42.2.389
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发表时间：
1992-02-01
期刊：
影响因子：
9.9
通讯作者：
ALARCON, TA
中科院分区：
文献类型：
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作者：
DELBRUTTO, OH;SANTIBANEZ, R;ALARCON, TA
我们回顾了203例脑囊虫病致癫痫患者的临床、脑电图和CT表现。 121例患者全身性发作，82例患者部分发作。 32例患者有局灶性体征，8例有视神经乳头水肿。 81例为全身性脑电图异常，16例为局灶性脑电图异常。 CT显示脑实质钙化53例，囊肿150例。 与多发性囊肿患者相比，单发囊肿患者局灶性体征的发生率增加，局灶性EEG异常仅存在于单发囊肿患者中。 50例患者失访。 其余153例患者随访28 +/- 6个月;其中31例有钙化，122例有囊肿。 每例患者在首次访视后开始使用抗惊厥药。 31例钙化患者无癫痫发作。 122例囊肿患者中有95例也接受了抗囊尾蚴药物治疗，其中79例（83%）癫痫发作得到控制。 相比之下，27例未接受抗囊尾蚴药物治疗的患者中只有7例（26%）控制了癫痫发作，表明抗囊尾蚴药物的使用与癫痫发作控制之间存在很强的相关性。 最后，在21名停用抗惊厥药的患者中，16名复发。
We reviewed clinical, EEG, and CT findings of 203 patients with epilepsy due to neurocysticercosis. Seizures were generalized in 121 patients and partial in 82. Thirty-two patients had focal signs and eight had papilledema. Eighty-one had generalized and 16 had focal EEG abnormalities. CT showed parenchymal brain calcifications in 53 patients and cysts in 150. There was an increased rate of focal signs in patients with single cysts as compared with patients with multiple cysts, and focal EEG abnormalities were present only in patients with single cysts. Fifty patients were lost to follow-up. The remaining 153 patients were followed for 28 +/- 6 months; of these, 31 had calcifications and 122 had cysts. Anticonvulsants were started after the first visit in every patient. The 31 patients with calcifications remained free of seizures. Ninety-five of the 122 patients with cysts were also treated with anticysticercal drugs; of these, 79 (83%) had control of seizures. In contrast, only seven (26%) of 27 patients who did not receive anticysticercal drugs had control of seizures, indicating a strong correlation between the use of anticysticercal drugs and seizure control. Finally, of the 21 patients in whom anticonvulsants were withdrawn, 16 had relapses.