Neurotrophic Factors for Retinal Ganglion Cell Neuropathy - With a Special Reference to Diabetic Neuropathy in the Retina
Neurotrophic Factors for Retinal Ganglion Cell Neuropathy - With a Special Reference to Diabetic Neuropathy in the Retina
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DOI：
10.2174/1573399810666140508121927
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发表时间：
2014-01-01
影响因子：
3.3
通讯作者：
Yamamoto, Shuichi
中科院分区：
文献类型：
--
作者：
Bikbova, Guzel;Oshitari, Toshiyuki;Yamamoto, Shuichi
糖尿病是一种对人口具有毁灭性影响的疾病。最近的数据显示，糖尿病视网膜病变患者的早期视网膜神经病变涉及脑源性神经营养因子的表达减少。视网膜神经节细胞（Retinal ganglion cells，RGC）神经病变是一种以视网膜神经节细胞死亡和轴突变性为特征的进行性视神经病变，在世界范围内可导致老年人失明。因此，需要拯救受损的RGC并抑制RGC损失和轴突变性的进展的神经保护疗法。本文综述了不同的神经营养因子对RGC神经病变相关性疾病眼RGC损伤的潜在神经保护治疗。
Diabetes mellitus is a disease with a devastating impact on population. Recent data revealed that early retinal neuropathy in patients with diabetic retinopathy involved a reduced expression of brain-derived neurotrophic factor. Retinal ganglion cells (RGC) neuropathy is a progressive optic nerve neuropathy with RGC death and axonal degeneration, and it leads to blindness in the elderly population worldwide. Thus, neuroprotective therapies that rescue damaged RGCs and inhibit the progression of RGC loss and axonal degeneration are needed. This review introduces potential neuroprotective therapies using different neurotrophic factors for damaged RGC in eyes with RGC neuropathy associated diseases.