F-SNP: computationally predicted functional SNPs for disease association studies.
F-SNP: computationally predicted functional SNPs for disease association studies.
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DOI：
10.1093/nar/gkm904
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发表时间：
2008-01
影响因子：
14.9
通讯作者：
Shatkay, Hagit
中科院分区：
文献类型：
--
作者：
Lee, Phil Hyoun;Shatkay, Hagit
功能性单核苷酸多态性（F-SNP）数据库整合了从16个生物信息学工具和数据库中获得的关于SNP功能效应的信息。这些作用在剪接、转录、翻译和翻译后水平被预测和指示。因此，该数据库有助于识别和关注对人类健康具有潜在有害影响的SNP。特别是，用户可以检索破坏已知有功能的基因组区域的SNP，包括剪接位点和转录调控区。用户还可以识别可能对蛋白质结构或功能产生有害影响、干扰蛋白质翻译或阻碍翻译后修饰的非同义SNP。网络界面使得能够通过多个起点和探索路线（例如，从SNP标识符、基因组区域、基因或目标疾病开始）容易地导航以获得信息。F-SNP数据库可在http://compbio.cs.queensu.ca/F-SNP/获得。
The Functional Single Nucleotide Polymorphism (F-SNP) database integrates information obtained from 16 bioinformatics tools and databases about the functional effects of SNPs. These effects are predicted and indicated at the splicing, transcriptional, translational and post-translational level. As such, the database helps identify and focus on SNPs with potential deleterious effect to human health. In particular, users can retrieve SNPs that disrupt genomic regions known to be functional, including splice sites and transcriptional regulatory regions. Users can also identify non-synonymous SNPs that may have deleterious effects on protein structure or function, interfere with protein translation or impede post-translational modification. A web interface enables easy navigation for obtaining information through multiple starting points and exploration routes (e.g. starting from SNP identifier, genomic region, gene or target disease). The F-SNP database is available at http://compbio.cs.queensu.ca/F-SNP/.
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