Diagnostic Accuracy of Screening Arterial Spin-Labeling MRI Using Hadamard Encoding for the Detection of Reduced CBF in Adult Patients with Ischemic Moyamoya Disease
Diagnostic Accuracy of Screening Arterial Spin-Labeling MRI Using Hadamard Encoding for the Detection of Reduced CBF in Adult Patients with Ischemic Moyamoya Disease
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DOI：
10.3174/ajnr.a7167
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发表时间：
2021-05-20
影响因子：
3.5
通讯作者：
Ogasawara, K.
中科院分区：
文献类型：
--
作者：
Setta, K.;Matsuda, T.;Ogasawara, K.
背景和目的：建议患有缺血性烟雾病的成人患者根据脑血流动力学进行选择性血运重建手术。本研究的目的是确定诊断准确性的动脉自旋标记MR成像使用阿达玛编码的多个postlabeling延迟检测减少CBFin such patients.MATERIALS和方法：37例患者进行了脑灌注SPECT和伪连续动脉自旋标记MR成像使用标准postlabeling延迟（1525毫秒）和阿达玛编码的多个postlabeling延迟。对于Hadamard编码的多个标记后延迟，基于从7个子团注获得的数据，结合不同的标记持续时间和标记后延迟，逐体素计算通过动脉通过时间校正的CBF。使用3D立体定位模板，我们自动将ROI放置在同侧小脑半球和5个MCA区域，然后计算MCA与小脑ROI的比值。
BACKGROUND AND PURPOSE:Adult patients with ischemic Moyamoya disease are advised to undergo selective revascularization surgery based on cerebral hemodynamics. The purpose of this study was to determine the diagnostic accuracy of arterial spin-labeling MR imaging using Hadamard-encoded multiple postlabeling delays for the detection of reduced CBF in such patients.MATERIALS AND METHODS:Thirty-seven patients underwent brain perfusion SPECT and pseudocontinuous arterial spin-labeling MR imaging using standard postlabeling delay (1525 ms) and Hadamard-encoded multiple postlabeling delays. For Hadamard-encoded multiple postlabeling delays, based on data obtained from the 7 sub-boluses with combinations of different labeling durations and postlabeling delays, CBF corrected by the arterial transit time was calculated on a voxel-by-voxel basis. Using a 3D stereotaxic template, we automatically placed ROIs in the ipsilateral cerebellar hemisphere and 5 MCA territories in the symptomatic cerebral hemisphere; then, the ratio of the MCA to cerebellar ROI was calculated.RESULTS:The area under the receiver operating characteristic curve for detecting reduced SPECT-CBF ratios (