ANATOMICAL EVIDENCE FOR CEREBELLAR AND BASAL GANGLIA INVOLVEMENT IN HIGHER COGNITIVE FUNCTION
ANATOMICAL EVIDENCE FOR CEREBELLAR AND BASAL GANGLIA INVOLVEMENT IN HIGHER COGNITIVE FUNCTION
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DOI：
10.1126/science.7939688
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发表时间：
1994-10-21
期刊：
影响因子：
56.9
通讯作者：
STRICK, PL
中科院分区：
文献类型：
--
作者：
MIDDLETON, FA;STRICK, PL
基底神经节和小脑中的神经元支配与认知功能有关的大脑皮层区域的可能性一直是一个人为的主题。在这里，单纯疱疹病毒1型（HSV 1）的逆行跨神经元转运被用来识别通过丘脑投射到灵长类前额叶皮层46区的皮层下神经元。这个皮层区域被认为与空间工作记忆有关。在大脑齿状核的限制区域和苍白球内段的许多神经元被来自46区的viss的跨神经元转运所标记。这些神经元的位置是不同的标记后，HSV 1运输从运动区的大脑皮层。这些观察结果定义了一个解剖学基板的基底神经节和小脑输出的参与更高的认知功能。
The possibility that neurons in the basal ganglia and cerebellum innervate areas of cerebral cortex that are involved in cognitive function has been a contriversial subject. Here, retrograde transneuronal transport of herpes simplex virus type 1 (HSV1) was used to identify subcortical neurons that project via the thalamus to area 46 of the primate prefrontal cortex. This cortical area is known to be involved in spatial working memory. Many neurons in restricted regions of the dentate nucleus of the cerebral and in the internal segment of the globus pallidus were labeled by transneuronal transport of visus from area 46. The location of these neurons was different from those labeled after HSV1 transport from motor areas of the cerebral cortex. These observations define an anatomical substrate for the involvement of basal ganglia and cerrebellar output in higher cognitive function.