EFFECT OF GABA ANTAGONISTS BICUCULLINE AND PICROTOXIN ON PRIMARY AFFERENT TERMINAL EXCITABILITY
EFFECT OF GABA ANTAGONISTS BICUCULLINE AND PICROTOXIN ON PRIMARY AFFERENT TERMINAL EXCITABILITY
复制标题
DOI：
10.1016/0006-8993(72)90282-x
复制
发表时间：
1972-01-01
期刊：
影响因子：
2.9
通讯作者：
ANDERSON, EG
中科院分区：
文献类型：
--
作者：
LEVY, RA;ANDERSON, EG
(1)用兴奋性测试技术确定了惊厥药荷包牡丹碱、印防己毒素和士的宁对腓肠肌Ia初级传入末梢极化的影响。这些末梢兴奋性的阶段性增加是通过对腘绳神经施加条件刺激而引起的。(2)荷包牡丹碱阻断了阶段性兴奋性增加，但没有明显改变末梢兴奋性的强直状态。(3)印防己毒素也阻止了阶段性兴奋性增加，此外还增加了末梢兴奋性的强直性兴奋性。(4)惊厥剂量的士的宁未能阻止阶段性兴奋性增加，但(5)GABA 拮抗剂荷包牡丹碱和印防己毒素阻断末端兴奋性阶段性增加的能力支持了突触前抑制通路含有 GABA 突触的假设。(6)虽然其位置仍不确定，但这些数据可以通过将该突触定位在远离传入末端的位置来最好地解释，在那里它的功能是去抑制紧张性活跃的中间神经元，从而使神经元去极化。终端。
(1)The effects of the convulsants bicuculline, picrotoxin, and strychnine on the polarization of gastrocnemius Ia primary afferent terminals have been ascertained with the excitability testing technique. Phasic increases in the excitability of these terminals were induced by conditioning stimuli applied to the hamstring nerve.(2)Bicuculline blocked the phasic excitability increases without appreciably altering the tonic state of terminal excitability.(3)Picrotoxin also blocked phasic increases and in addition increased the tonic excitability of the terminal.(4)Convulsant doses of strychnine failed to block phasic excitability increases but in larger doses increased tonic excitability.(5)The capacity of the GABA antagonists bicuculline and picrotoxin to block phasic increases in terminal excitability supports the hypothesis that the presynaptic inhibitory pathway contains a GABA synapse.(6)Although its position remains uncertain, these data can best be explained by locating this synapse at a site removed from the afferent terminal, where it functions to disinhibit tonically active interneurons which depolarize the terminal.