Evidence of inflammation and predisposition toward metabolic syndrome after pre-eclampsia
Evidence of inflammation and predisposition toward metabolic syndrome after pre-eclampsia
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DOI：
10.1016/j.preghy.2015.09.007
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发表时间：
2015-10-01
影响因子：
2.2
通讯作者：
Smith, Graeme N.
中科院分区：
文献类型：
--
作者：
Murphy, Malia S. Q.;Tayade, Chandrakant;Smith, Graeme N.
背景：子痫前期是一种以过度炎症和代谢反应为特征的妊娠期高血压疾病。有PE病史的女性患代谢综合征(METS)和心血管疾病的风险增加，尽管这种关联的病理生理学基础尚不清楚。本研究旨在比较有和没有PE病史的妇女的血浆免疫调节因子水平与心血管和蛋氨酸代谢综合征危险因素的存在。研究设计：收集无并发症妊娠(n=28)和合并PE(n=35)的妇女产后5-7个月的母体血浆和一般健康调查数据。使用高灵敏度细胞因子谱阵列分析了14种免疫调节因子的母体血浆样本。结果：与对照组相比，有PE病史的女性表现出更高的血压和血浆甘油三酯水平，尽管肥胖、空腹胆固醇和血糖的参数相似。尽管对照组和PE组的血浆免疫调节细胞因子水平相似，但PE组的生物物理参数与血浆细胞因子之间呈现出独特的相关模式。特别是，在没有临床证据的女性中，血浆IL-23、MIP-1α、IL-1β和干扰素-γ水平与METS诊断参数显著相关。结论：我们在PE后一年内报道了促炎标志物与METS标准之间的独特关联。有PE病史但其他方面健康的女性的亚临床炎症可能表明这些女性对代谢紊乱，特别是蛋氨酸敏感。(C)2015年国际妊娠期高血压研究学会。爱思唯尔出版，版权所有。
Background: Pre-eclampsia (PE) is a hypertensive disorder of pregnancy characterized by exaggerated inflammatory and metabolic responses. Women with a history of PE are at increased risk of the metabolic syndrome (MetS) and cardiovascular disease although the pathophysiological underpinnings of this association remain unclear. This study aimed to compare levels of plasma immunoregulatory factors with the presence of cardiovascular and MetS risk factors in women with and without a history of PE.Study design: Maternal plasma and general health survey data were collected from women 5 to 7 months postpartum of uncomplicated pregnancies (n = 28) and pregnancies complicated by PE (n = 35). Maternal plasma samples were analyzed for 14 immunoregulatory factors using a high-sensitivity cytokine profiling array. Cardiovascular risk profiles were compiled on each participant for comparison against cytokine data.Results: Women with a history of PE exhibited increased blood pressure and plasma triglyceride levels compared to controls, although similar for parameters of obesity, fasting cholesterols, and glucose. While plasma levels of immunoregulatory cytokines were similar between control and PE subjects, PE subjects exhibited unique patterns of correlation between biophysical parameters and plasma cytokines. In particular, plasma IL-23, MIP-1 alpha, IL-1 beta and IFN-gamma levels were significantly correlated with parameters considered for MetS diagnosis in women without clinical evidence of the syndrome.Conclusions: We report unique associations between pro-inflammatory markers and MetS criteria within a year following PE. Subclinical inflammation in women with a history of PE who are otherwise healthy may indicate a sensitization of these women toward metabolic disturbances, in particular MetS. (C) 2015 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.