Fractalkine: A Survivor's Guide Chemokines as Antiapoptotic Mediators
Fractalkine: A Survivor's Guide Chemokines as Antiapoptotic Mediators
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DOI：
10.1161/atvbaha.111.237412
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发表时间：
2012-03-01
影响因子：
8.7
通讯作者：
Greaves, David R.
中科院分区：
文献类型：
--
作者：
White, Gemma E.;Greaves, David R.
趋化因子是一类低分子量蛋白质家族，在稳态和病理条件下对细胞定向迁移至关重要。Fractalkine（CX 3CL 1）是一种不寻常的趋化因子，可作为可溶性或膜结合介体，并通过G蛋白偶联趋化因子受体CX 3CR 1（在单核细胞、自然杀伤细胞、T细胞和平滑肌细胞上表达）发出信号。越来越多的证据表明，fractalkine，除了其在白细胞的趋化性和粘附作用，支持多种细胞类型的生存在稳态和炎症。本文综述了从几种疾病模型中获得的证据，暗示了fractalkine的抗凋亡功能，并显示了这与动脉粥样硬化和其他血管疾病的病理学有关。我们讨论了与其他趋化因子不同，fractalkine的关键作用是否是促进细胞存活，以及这是否对血管疾病有影响。（Arterioscler Thromb Vasc Biol.2012;32：589-594.）
Chemokines are a family of low-molecular-weight proteins essential to the directed migration of cells under homeostatic and pathological conditions. Fractalkine (CX3CL1) is an unusual chemokine that can act as either a soluble or membrane-bound mediator and signals through the G protein-coupled chemokine receptor CX3CR1, expressed on monocytes, natural killer cells, T cells, and smooth muscle cells. Accumulating evidence suggests that fractalkine, in addition to its role in chemotaxis and adhesion of leukocytes, supports the survival of multiple cell types during homeostasis and inflammation. This review presents the evidence obtained from several disease models implying an antiapoptotic function for fractalkine and shows how this is relevant to the pathology of atherosclerosis and other vascular diseases. We discuss whether the key role of fractalkine, unlike other chemokines, is the promotion of cell survival and whether this has implications for vascular disease. (Arterioscler Thromb Vasc Biol. 2012;32:589-594.)