Extracellular matrix signaling: integration of form and function in normal and malignant cells
Extracellular matrix signaling: integration of form and function in normal and malignant cells
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DOI：
10.1016/s0955-0674(98)80040-9
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发表时间：
1998-10-01
影响因子：
7.5
通讯作者：
Bissell, MJ
中科院分区：
文献类型：
--
作者：
Boudreau, N;Bissell, MJ
越来越多的研究已经建立了细胞外基质（ECM）-整合素，生长因子信号传导和细胞-细胞粘附分子之间的相互联系。ECM依赖性组织特异性基因表达也与染色质重塑有关。关于组织形态发生和分化，已经在ECM和同源框形态调节基因之间建立了串扰。这些连接中的每一个都受到细胞微环境和所得组织形式的深刻影响。因此，对于实现分化表型的细胞，ECM分子及其受体必须整合形式和功能。相反，突变的基因和与微环境的异常相互作用会破坏这种整合，往往导致恶性转化。
A growing number of studies have established reciprocal linkages between extracellular matrix (ECM)-integrins, growth factor signaling and cell-cell adhesion molecules. ECM-dependent tissue-specific gene expression has also been linked to chromatin remodeling. With respect to tissue morphogenesis and differentiation, crosstalk has been established between the ECM and the homeobox morphoregulatory genes. Each of these linkages is profoundly influenced by the cell's microenvironment and the resulting tissue form, Thus for a cell to achieve a differentiated phenotype, the ECM molecules and their receptors must integrate both form and function. In contrast, mutated genes and aberrant interactions with the microenvironment conspire to undermine this integration, often resulting in malignant transformation.