Escitalopram treatment for premature ejaculation has a negative effect on semen parameters
Escitalopram treatment for premature ejaculation has a negative effect on semen parameters
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DOI：
10.1038/ijir.2011.35
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发表时间：
2011-11-01
影响因子：
2.6
通讯作者：
Sarica, K.
中科院分区：
文献类型：
--
作者：
Koyuncu, H.;Serefoglu, E. C.;Sarica, K.
本研究的目的是确定长期艾司西酞普兰治疗对终身早泄（PE）患者精液参数的影响。在2008年11月至2010年1月期间，评价了因自我报告的PE投诉而入住泌尿科门诊的患者。记录患者的病史和性史，并要求符合国际性医学会定义的终身PE患者（共25例）记录1个月的阴道内射精潜伏期（IELT），完成早泄诊断工具（PEDT）问卷并提供精液样本。之后，患者每天接受10 mg艾司西酞普兰，持续12周，并在治疗的第一个月和第三个月接受对照访视。在对照访视期间，再次给予PEDT，同时记录IELT并重新检查精液样本。比较两组在基线、第1个月和第3个月的PEDT评分、IELT算术平均值和精液分析结果。在治疗的第三个月，检测到平均IELT显著增加，PEDT评分显著降低。然而，与基线精液测量值相比，精子浓度、活力和形态均显著降低。每日艾司西酞普兰治疗影响终身PE患者的精液参数需要更大系列的进一步研究，以了解其他5-羟色胺再摄取抑制剂是否有类似的副作用，并揭示其确切的机制。International Journal of Imperial Research（2011）23，257-261; doi：10.1038/ijir.2011.35; 2011年7月21日在线发表
The aim of this study was to determine the impact of long-term escitalopram treatment on semen parameters of patients with lifelong premature ejaculation (PE). Between November 2008 and January 2010, patients admitted to urology outpatient clinic with a self-reported complaint of PE were evaluated. Medical and sexual history of patients were recorded and patients with lifelong PE (a total of 25 patients) who met the International Society of Sexual Medicine definition were asked to record their intravaginal ejaculatory latency time (IELT) for 1 month, complete Premature Ejaculation Diagnostic Tool (PEDT) questionnaire and give semen samples. Afterwards, patients received 10 mg escitalopram daily for 12 weeks and were invited for control visits at first and third month of treatment. During control visits, PEDT was administered again whereas IELTs were recorded and semen samples were re-examined. PEDT scores, arithmetic means of IELTs and results of semen analyses, which were recorded at baseline, first and third month were compared. At the third month of treatment, a significant increase in mean IELTs and a significant decrease in PEDT scores were detected. However there was a significant decrease in sperm concentration, motility and morphology when compared with the baseline semen measures. Daily escitalopram treatment effects the semen parameters of patients with lifelong PE. Further investigations with larger series are needed to see whether other serotonin reuptake inhibitors have similar side effects and to expose the exact mechanism underlying it. Different treatment modalities should be suggested to patients who desire fertility. International Journal of Impotence Research (2011) 23, 257-261; doi: 10.1038/ijir.2011.35; published online 21 July 2011