Association between the time to surgery and survival among patients with colon cancer: A population-based study
Association between the time to surgery and survival among patients with colon cancer: A population-based study
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DOI：
10.1016/j.ejso.2017.04.014
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发表时间：
2017-08-01
期刊：
影响因子：
3.8
通讯作者：
Booth, C. M.
中科院分区：
文献类型：
--
作者：
Flemming, J. A.;Nanji, S.;Booth, C. M.
与结肠癌手术时间（TTS）和生存率相关的因素尚未得到充分研究。癌症护理安大略建议手术42天内诊断和90%的患者符合这一基准，我们描述的因素与TI的和生存在常规clinical practice.Methods：回顾性人群为基础的队列研究的患者接受选择性结肠切除术后，诊断结肠癌在加拿大安大略，从2002年至2008年，直到2012年。在第42天和第90天，使用多变量对数二项和分位数回归确定与TTS相关的因素。TTS和癌症特异性（CSS）和总生存期（OS）之间的关联进行了研究，使用多变量考克斯regression.Results：4326例患者，中位年龄71岁，52%为男性。中位TTS为24天（IQR 14-37）;第90百分位数为56天。与TTS >= 42天和>第90百分位数相关的因素包括年龄、共病、外科医生数量和I期疾病（所有P < 0.05）。在TTS为42天或第90百分位数的患者中，那些>= 80岁的患者比42天或>第90百分位数的患者等待两周的时间与OS或CSS.Conclusion无关：年龄，合并症和癌症分期与TTS相关。TTS和CSS或OS之间没有关联。（C）2017 Elsevier Ltd，BASO类似于癌症外科协会和欧洲外科肿瘤学会。All rights reserved.
Factors associated with time-to-surgery (TTS) and survival in colon cancer has not been well studied. Cancer Care Ontario recommends surgery within 42 days of diagnosis and that 90% of patients meet this benchmark We describe factors associated with TI'S and survival in routine clinical practice.Methods: Retrospective population-based cohort study of patients receiving elective colonic resection after diagnosis of colon cancer in Ontario, Canada from 2002 to 2008 followed until 2012. Factors associated with TTS were identified using multivariate log-binomial and Quantile regression at 42 days and 90th percentiles. The association between TTS and cancer-specific (CSS) and overall survival (OS) were examined using multivariate Cox regression.Results: 4326 patients; median age 71 years and 52% male. Median TTS was 24 days (IQR 14-37); at the 90th percentile 56 days. Factors associated with TTS >= 42 days and >90th percentile included older age, co-morbid illness, surgeon volume, and stage I disease (P < 0.05 for all). In patients whose TTS was either at 42 days or 90th percentile, those >= 80 years old waited two weeks longer than those 42 days or >90th percentile was not associated with OS or CSS.Conclusion: Age, co-morbidity, and stage of cancer are associated with TTS. There was no association between TTS and CSS or OS. (C) 2017 Elsevier Ltd, BASO similar to The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.