Role of Mitophagy in the Pathogenesis of Stroke: From Mechanism to Therapy.
Role of Mitophagy in the Pathogenesis of Stroke: From Mechanism to Therapy.
复制标题
线粒体自噬在中风发病机制中的作用：从机制到治疗
DOI：
10.1155/2022/6232902
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发表时间：
2022
影响因子：
--
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Zhong WJ;Yang XS;Zhou H;Xie BR;Liu WW;Li Y
线粒体可以向组织提供三磷酸腺苷（ATP），在病理过程中调节代谢，也参与脑卒中后神经元损伤的病理生理。近年来的研究表明，选择性自噬可能在脑卒中的病理生理过程中发挥重要作用，尤其是有丝自噬。通常由PINK1/ parkinson -independent通路或PINK1/ parkinson -dependent通路介导。此外，线粒体自噬可能是脑卒中治疗的潜在靶点，因为控制线粒体自噬在脑卒中中具有神经保护作用。本文简要综述了线粒体自噬的最新研究进展，介绍了线粒体自噬在脑卒中发病机制中的作用，重点介绍了靶向线粒体自噬治疗脑卒中的策略，最后提出了靶向线粒体自噬治疗脑卒中的几个问题。
Mitochondria can supply adenosine triphosphate (ATP) to the tissue, which can regulate metabolism during the pathologic process and is also involved in the pathophysiology of neuronal injury after stroke. Recent studies have suggested that selective autophagy could play important roles in the pathophysiological process of stroke, especially mitophagy. It is usually mediated by the PINK1/Parkin-independent pathway or PINK1/Parkin-dependent pathway. Moreover, mitophagy may be a potential target in the therapy of stroke because the control of mitophagy is neuroprotective in stroke in vitro and in vivo. In this review, we briefly summarize recent researches in mitophagy, introduce the role of mitophagy in the pathogenesis of stroke, then highlight the strategies targeting mitophagy in the treatment of stroke, and finally propose several issues in the treatment of stroke by targeting mitophagy.
影响因子：
13.3
作者：
Ju JS;Miller SE;Jackson E;Cadwell K;Piwnica-Worms D;Weihl CC
通讯作者：
Weihl CC