Associations between home dampness and presence of molds with asthma and allergic symptoms among young children in the tropics
Associations between home dampness and presence of molds with asthma and allergic symptoms among young children in the tropics
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DOI：
10.1111/j.1399-3038.2007.00544.x
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发表时间：
2007-08
影响因子：
4.4
通讯作者：
K. Tham;M. Zuraimi;D. Koh;F. Chew;P. Ooi
中科院分区：
文献类型：
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作者：
K. Tham;M. Zuraimi;D. Koh;F. Chew;P. Ooi
现有文献表明，家庭潮湿增加室内霉菌负担，并与温带环境中幼儿过敏症状增加有关。在热带地区，没有任何类似性质的研究报告，那里的条件通常是高温和潮湿，全年降雨。评估热带环境中儿童卧室潮湿和室内霉菌的幼儿（1.5-6岁）当前哮喘的患病率与过敏症状之间是否存在关联。采用扩展和修改的ISAAC -国际儿童哮喘和过敏研究-问卷对随机选择的120家日托中心的6794名儿童（4759名回答- 70%）进行了一项横断面研究，以评估哮喘和过敏。获得了关于人口统计学、家庭湿度和室内霉菌的可见存在的具体信息。采用考克斯比例风险回归模型确定患病率比（PR）和95%置信区间（CI），并假设横断面研究中推荐的风险期恒定。对计算的PR进行了年龄、性别、种族、社会经济地位、住房类型、母亲和父亲特应性、呼吸道感染、环境烟草烟雾（ETS）暴露和食物过敏控制。校正潜在混杂效应后，观察到家庭潮湿与当前鼻结膜炎症状显著相关（校正PR 1.53，95% CI：1.00-2.33）。霉菌的可见存在与鼻炎（PR 1.55，95% CI：1.16-2.07）和鼻结膜炎（PR 2.38，95% CI：1.51-3.75）的当前症状显著相关。儿童卧室的室内潮湿和霉菌是与新加坡幼儿过敏症状相关的重要危险因素。
Existing literature has shown that home dampness increases indoor mold burden and is associated with increased allergic symptoms among young children in temperate environments. There is no report of any studies of similar nature in the tropics where conditions are characterized typically by high temperatures and humidity with rainfall throughout the year. To evaluate if there are associations between the prevalence of current asthma and allergic symptoms in young children (age 1.5–6 yr) with dampness and indoor mold in children's bedrooms in a tropical environment. A cross‐sectional study adopting an expanded and modified ISAAC –International Study on Asthma and Allergies in Children– questionnaire for the evaluation of asthma and allergies was conducted on 6794 children (4759 responded – 70%) attending 120 randomly selected daycare centers. Specific information on demographics, home dampness, and the visible presence of indoor molds were obtained. The prevalence ratios (PR) and 95% confidence interval (CI) were determined by Cox proportional hazard regression model with assumption of a constant risk period as recommended for cross‐sectional studies. The calculated PRs were controlled for age, gender, ethnicity, socio‐economic status, type of housing, maternal and paternal atopy, respiratory infections, environmental tobacco smoke (ETS) exposure, and food allergy. After adjusting for potential confounding effects, home dampness was observed to be significantly associated with current symptoms of rhinoconjunctivitis (adjusted PR 1.53, 95% CI: 1.00–2.33). The visible presence of mold was significantly associated with current symptoms of rhinitis (PR 1.55, 95% CI: 1.16–2.07) and rhinoconjunctivitis (PR 2.38, 95% CI: 1.51–3.75). Indoor dampness and mold in children's bedroom are important risk factors associated with allergic symptoms in young children in Singapore.