Yersinia enterocolitica induces epithelial barrier dysfunction through regional tight junction changes in colonic HT-29/B6 cell monolayers
Yersinia enterocolitica induces epithelial barrier dysfunction through regional tight junction changes in colonic HT-29/B6 cell monolayers
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DOI：
10.1038/labinvest.2010.180
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发表时间：
2011-02-01
影响因子：
5
通讯作者：
Schulzke, Joerg D.
中科院分区：
文献类型：
--
作者：
Hering, Nina A.;Richter, Jan F.;Schulzke, Joerg D.
小肠结肠炎耶尔森氏菌是引起急性胃肠炎的常见原因。本研究旨在阐明屏障功能障碍和腹泻的机制。人结肠HT-29/B6细胞暴露于小肠结肠炎耶尔森菌后，跨上皮阻力由404+/-23降至163+/-21欧米伽厘米(2)(P
Yersinia enterocolitica is a common cause of acute gastroenteritis. This study aimed to clarify the mechanisms leading to barrier dysfunction and diarrhea. Exposure of human colonic HT-29/B6 cells to Y. enterocolitica resulted in a decrease in transepithelial resistance from 404 +/- 23 to 163 +/- 21 Omega cm(2) (P