Mitochondrial dynamics in yeast cell death and aging
Mitochondrial dynamics in yeast cell death and aging
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DOI：
10.1042/bst0391520
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发表时间：
2011-10-01
影响因子：
3.9
通讯作者：
Westermann, Benedikt
中科院分区：
文献类型：
--
作者：
Braun, Ralf J.;Westermann, Benedikt
线粒体在细胞程序性死亡和衰老中起着至关重要的作用。不同的刺激激活不同的依赖于线粒体的细胞死亡途径，衰老与线粒体损伤的逐步增加有关，最终导致氧化应激和细胞功能障碍。线粒体是高度动态的细胞器，不断融合和分裂，形成相互连接的线粒体网络或分离的片段化线粒体。这些过程被认为提供了线粒体质量控制系统，并使线粒体区室能够有效地适应细胞的代谢需求。面包酵母，酿酒酵母，是程序性细胞死亡和衰老研究的既定模型。本综述总结了线粒体形态是如何改变诱导细胞死亡或衰老，以及这与酵母中不同细胞死亡途径的诱导如何相关。我们强调线粒体融合和裂变机制的组成部分的作用，影响和调节细胞死亡和衰老。
Mitochondria play crucial roles in programmed cell death and aging. Different stimuli activate distinct mitochondrion-dependent cell death pathways, and aging is associated with a progressive increase in mitochondrial damage, culminating in oxidative stress and cellular dysfunction. Mitochondria are highly dynamic organelles that constantly fuse and divide, forming either interconnected mitochondrial networks or separated fragmented mitochondria. These processes are believed to provide a mitochondrial quality control system and enable an effective adaptation of the mitochondrial compartment to the metabolic needs of the cell. The baker's yeast, Saccharomyces cerevisiae, is an established model for programmed cell death and aging research. The present review summarizes how mitochondrial morphology is altered on induction of cell death or on aging and how this correlates with the induction of different cell death pathways in yeast. We highlight the roles of the components of the mitochondrial fusion and fission machinery that affect and regulate cell death and aging.