Frequent microsatellite instability in primary small cell lung cancer.
Frequent microsatellite instability in primary small cell lung cancer.
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发表时间：
1994-04
期刊：
影响因子：
11.2
通讯作者：
A. Merlo;M. Mabry;E. Gabrielson;R. Vollmer;S. Baylin;D. Sidransky
中科院分区：
文献类型：
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作者：
A. Merlo;M. Mabry;E. Gabrielson;R. Vollmer;S. Baylin;D. Sidransky
遗传性非息肉病性结直肠癌微卫星序列的改变这种微卫星的不稳定性是由于在一些激酶的错配修复基因hMSH2染色体2p上的种系突变。虽然在其他遗传性非息肉病性结直肠癌相关肿瘤（包括子宫内膜癌和胃癌）中也有微卫星改变的报道，但在大多数其他主要肿瘤中未检测到这种改变。我们发现33例原发性小细胞肺癌中有15例（45%）表现出微卫星位点的改变，包括（CA）n二核苷酸重复序列的缺失或扩增，这些肿瘤在遗传性非息肉病性结直肠癌综合征中没有发现。在这15种肿瘤中的8种中，超过10%的所有检测等位基因检测到微卫星不稳定性。然而，显示不稳定性的小细胞肺癌包含广泛的等位基因丢失，并且具有一致的不良预后。这些结果大大扩展了已知的微卫星不稳定性肿瘤谱。
Alterations in microsatellite sequences characterize hereditary nonpolyposis colorectal cancer. This microsatellite instability is due in some kindreds to a germline mutation of the mismatch repair gene hMSH2 on chromosome 2p. Although microsatellite alterations have been reported in other hereditary nonpolyposis colorectal cancer-associated tumors including endometrial and gastric cancers, such changes were not detected in most other major neoplasms. We found that 15 of 33 (45%) primary small cell lung cancers, tumors not found in the hereditary nonpolyposis colorectal cancer syndrome, displayed alterations of microsatellite loci which consisted of deletions or expansions of (CA)n dinucleotide repeats. In 8 of these 15 neoplasms, microsatellite instability was detected in more than 10% of all tested alleles. However, small cell lung cancers that revealed instability contained widespread allelic loss and had a uniformly poor prognosis. These results expand considerably the known spectrum of tumors with microsatellite instability.