Urinary Excretion of MicroRNA-126 Is a Biomarker for Hemangioma Proliferation.
Urinary Excretion of MicroRNA-126 Is a Biomarker for Hemangioma Proliferation.
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DOI：
10.1097/prs.0000000000003349
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发表时间：
2017-06
影响因子：
3.6
通讯作者：
Gordillo GM
中科院分区：
文献类型：
--
作者：
Biswas A;Pan X;Meyer M;Khanna S;Roy S;Pearson G;Kirschner R;Witman P;Faith EF;Sen CK;Gordillo GM
血管瘤是一种独特的内皮细胞肿瘤，会自发展开，这使得很难解释对治疗的反应。这项工作的目的是确定婴儿血管瘤患儿尿液中的潜在生物标志物，这将有助于测试新的治疗方法。对患有血管瘤的儿童和年龄匹配的健康对照进行了一项前瞻性纵向研究，以确定microRNA (miR)-126是否在胎儿内皮细胞中含量很高，在患病儿童的尿液中含量更高。前瞻性超声测量血管瘤大小和血流速度作为次要终点，以记录未经治疗的血管瘤的纵向变化。在患有增殖性血管瘤的儿童中，尿miR-126水平显著升高，尿miR丰度的相对水平与血管瘤大小相关。与健康对照组相比，血管瘤患者miR丰度水平升高。超声数据显示，血管瘤增生通常在6至9个月大时停止。当血管瘤增殖停止时，患有血管瘤的儿童的尿miR-126水平下降到健康年龄匹配对照组的水平。这是首次报道的在血管瘤患儿尿液中发现miR生物标志物的结果。测量尿中miR-126的水平可能用于监测血管瘤对治疗的反应。
Hemangiomas are unique endothelial cell tumors that spontaneously involute, which makes it difficult to interpret response to therapies. The objective of this work was to identify a potential biomarker in the urine of children with infantile hemangiomas that would facilitate testing new therapies. A prospective longitudinal study in children with hemangiomas and age matched healthy controls was performed to determine whether microRNA (miR)-126, which is highly abundant in fetal endothelial cells, was more abundant in the urine of affected children. Prospective ultrasound measurements of hemangioma size and blood flow velocity were obtained as secondary endpoints to document longitudinal changes in untreated hemangiomas. Urinary miR-126 levels were significantly elevated in children with proliferating hemangiomas and relative levels of urinary miR abundance correlated with hemangioma size. Hemangiomas had elevated levels of miR abundance compared to healthy controls. Ultrasound data revealed that hemangioma proliferation typically stopped between 6 to 9 months of age. When hemangioma proliferation stopped urinary miR-126 levels in children with hemangiomas dropped to levels observed in healthy age matched controls. These are the first reported results to identify a potential miR biomarker in the urine of children with hemangiomas. Measurement of urinary levels of miR-126 could potentially be used to monitor hemangioma response to therapies.