Streptococcus pneumoniae infections and bacteremia in patients with acquired immune deficiency syndrome, with report of a pneumococcal vaccine failure.
Streptococcus pneumoniae infections and bacteremia in patients with acquired immune deficiency syndrome, with report of a pneumococcal vaccine failure.
复制标题
获得性免疫缺陷综合征患者的肺炎链球菌感染和菌血症，有肺炎球菌疫苗失败的报告。
DOI：
10.1164/arrd.1984.130.6.1174
复制
发表时间：
1984
期刊：
影响因子：
--
通讯作者：
RahalJr,JJ
中科院分区：
文献类型：
--
作者：
Simberkoff,MS;ElSadr,W;Schiffman,G;RahalJr,JJ
1982年1月1日至1983年6月30日，纽约退伍军人管理局医疗中心因获得性免疫缺陷综合征（AIDS）住院的35例患者中，5例患者有肺炎链球菌感染。这些患者中有3例有肺炎球菌菌血症，2例有肺炎而无菌血症。27个细菌。在同一时期，在该医院医疗服务部门收治的5，143名非艾滋病患者中发生了肺炎感染。因此，肺炎球菌菌血症更可能发生在艾滋病患者比一般住院人群（x2= 26，p = < 0.001）。两例菌血症感染由S.肺炎4型。其中一例发生在5个月前接种14价肺炎球菌疫苗的患者中。有没有显着差异的放射免疫测定抗体浓度4型肺炎球菌多糖在连续的血清样本收集从这个病人，调理剂滴度，这种生物体没有检测到。它的结论是肺炎球菌感染是非常常见的艾滋病患者，并可能无法通过积极的免疫预防。
Five patients hadStreptococcus pneumoniaeinfections among the 35 hospitalized with acquired immune deficiency syndrome (AIDS) at the New York Veterans Administration Medical Center between January 1, 1982, and June 30, 1983. Three of these patients had pneumococcal bacteremia and 2 had pneumonia without bacteremia. Twenty-seven bacteremicS. pneumoniaeinfections occurred among 5,143 patients without AIDS admitted to the Medical Service of this hospital during the same period. Thus, pneumococcal bacteremia was more likely to occur in patients with AIDS than in the general hospitalized population (x2= 26, p = < 0.001). Two of the bacteremic infections were caused by S. pneumoniae type 4. One of these occurred in a patient who had been inoculated with the 14 valent pneumococcal vaccine 5 months earlier. There were no significant differences in concentrations of radioimmunoassay antibody to type 4 pneumococcal polysaccharide in sequential serum samples collected from this patient, and opsonic titers to this organism were not detected. It is concluded that pneumococcal infections are very common among patients with AIDS, and may not be prevented by active immunoprophylaxis.