Ruthenium-catalyzed arylation of 2-alkenylpyridines with aryl bromides:: Alternative E,Z-selectivity to Mizoroki-Heck reaction
Ruthenium-catalyzed arylation of 2-alkenylpyridines with aryl bromides:: Alternative E,Z-selectivity to Mizoroki-Heck reaction
复制标题
DOI：
10.1021/ol051654l
复制
发表时间：
2005-09-01
期刊：
影响因子：
5.2
通讯作者：
Inoue, Y
中科院分区：
文献类型：
--
作者：
Oi, S;Sakai, K;Inoue, Y
[图]2-烯基吡啶与芳基溴的区域选择性和立体选择性芳基化由特定的 Ru(II)-膦配合物催化，得到 β-芳基化 (Z)-2-烯基吡啶，其中芳基部分顺式引入吡啶基。这种几何选择性与 Mizoroki-Heck 反应形成鲜明对比。
[Graphics]Regio- and stereoselective arylation of 2-alkenylpyridines with aryl bromides is catalyzed by specific Ru(II)-phosphine complexes affording beta-arylated (Z)-2-alkenylpyridines, in which the aryl moiety is introduced cis to the pyridyl group. This geometrical selectivity is in sharp contrast to the Mizoroki-Heck reaction.