Gene-expression signatures of Atlantic salmon's plastic life cycle
Gene-expression signatures of Atlantic salmon's plastic life cycle
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DOI：
10.1016/j.ygcen.2009.04.021
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发表时间：
2009-09-15
影响因子：
2.7
通讯作者：
Hofmann, Hans A.
中科院分区：
文献类型：
--
作者：
Aubin-Horth, Nadia;Letcher, Benjamin H.;Hofmann, Hans A.
基因组表达如何作为生活史变异的函数而不同在很大程度上是未知的。大西洋鲑鱼具有极端的另类生活史。我们通过比较成熟运动鞋雄性和不成熟雄性以及早期移民和晚期移民的大脑表达谱，定义了野生鲑鱼在两个不同生命阶段的基因表达特征。除了生命阶段特异性的签名，我们发现了一个令人惊讶的大基因集，在两个生活史过渡中以相似的幅度，但在相反的方向进行差异调节。我们认为，这种共变不是许多独立的细胞和分子开关在同一个方向的结果，而是代表了一个或很少的主调节器精心策划的生理转变的分子等价物。(C)2009 Elsevier Inc. All rights reserved.
How genomic expression differs as a function of life history variation is largely unknown. Atlantic salmon exhibits extreme alternative life histories. We defined the gene-expression signatures of wild-caught salmon at two different life stages by comparing the brain expression profiles of mature sneaker males and immature males, and early migrants and late migrants. In addition to life-stage-specific signatures, we discovered a surprisingly large gene set that was differentially regulated-at similar magnitudes, yet in opposite direction-in both life history transitions. We suggest that this co-variation is not a consequence of many independent cellular and molecular switches in the same direction but rather represents the molecular equivalent of a physiological shift orchestrated by one or very few master regulators. (C) 2009 Elsevier Inc. All rights reserved.