Prognostic value of very low plasma concentrations of troponin T in patients with stable chronic heart failure
Prognostic value of very low plasma concentrations of troponin T in patients with stable chronic heart failure
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DOI：
10.1161/circulationaha.106.655076
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发表时间：
2007-09-11
期刊：
影响因子：
37.8
通讯作者：
Cohn, Jay N.
中科院分区：
文献类型：
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作者：
Latini, Roberto;Masson, Serge;Cohn, Jay N.
循环心肌肌钙蛋白T是心肌细胞损伤的标志物，可预测心力衰竭（HF）患者的不良结局，但仅在一小部分慢性稳定性HF患者中可检测到。我们评估了循环心肌肌钙蛋白T在稳定性慢性HF患者中的预后价值，采用传统的（cTnT）和一种新的商业化前高灵敏度检测（hsTnT）。方法和结果：对4053例参加缬沙坦心力衰竭试验（Val-HeFT）的慢性心力衰竭患者进行了血浆肌钙蛋白T测定。肌钙蛋白T在10.4%的人群中可通过cTnT检测试剂盒检出（检测限
Background-Circulating cardiac troponin T, a marker of cardiomyocyte injury, predicts adverse outcome in patients with heart failure (HF) but is detectable in only a small fraction of those with chronic stable HF. We assessed the prognostic value of circulating cardiac troponin T in patients with stable chronic HF with a traditional (cTnT) and a new precommercial highly sensitive assay (hsTnT). Methods and Results-Plasma troponin T was measured in 4053 patients with chronic HF enrolled in the Valsartan Heart Failure Trial (Val-HeFT). Troponin T was detectable in 10.4% of the population with the cTnT assay ( detection limit