Red Blood Cells Parameters in Patients with Acute Schizophrenia, Unipolar Depression and Bipolar Disorder.
Red Blood Cells Parameters in Patients with Acute Schizophrenia, Unipolar Depression and Bipolar Disorder.
复制标题
急性精神分裂症、单相抑郁症和双相情感障碍患者的红细胞参数。
DOI：
10.24869/psyd.2018.323
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发表时间：
2018
影响因子：
--
通讯作者：
Ewa Szczepocka
中科院分区：
文献类型：
--
作者：
A. Wysokiński;Ewa Szczepocka
背景
没有研究比较精神分裂症、双相情感障碍和单相抑郁症患者的红细胞参数。本研究的目的是比较红细胞参数的差异精神分裂症（SHZ）、单相抑郁症（UD）和双相情感障碍（BIP）患者的红细胞计数（RBC）、红细胞压积（HCT）、血红蛋白（HGB）、平均红细胞体积（MCV）、平均红细胞血红蛋白（MCH）、平均红细胞血红蛋白浓度（MCHC）和红细胞分布宽度（RDW）：双相抑郁（BD）和躁狂（BM）。
受试者和方法
这是一项纳入2381例患者的回顾性、横断面、自然主义研究（SHZ n=1244; UD n=794; BIP n=343，BD n=259，BM n=84）。
结果
所有红细胞参数在研究组之间存在显著差异（p<0.001）。年龄和性别可能影响各种红细胞参数。
结论
精神分裂症、单相抑郁症和双相情感障碍的红细胞参数存在差异。与精神分裂症患者相比，情感性精神障碍患者贫血或红细胞参数异常的比例明显增高。各年龄组MCV、RDW与年龄呈正相关，其它参数与年龄呈负相关。
BACKGROUND
There are no studies comparing red blood cell parameters between patients with schizophrenia, bipolar disorder and unipolar depression. The aim of this study was to compare differences in erythrocyte parameters (red blood cell count (RBC), hematocrit (HCT), hemoglobin (HGB), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and red blood cell distribution width (RDW)) in patients with schizophrenia (SHZ), unipolar depression (UD) and bipolar disorder (BIP): bipolar depression (BD) and mania (BM).
SUBJECTS AND METHODS
This was a retrospective, cross-sectional, naturalistic study of 2381 patients (SHZ n=1244; UD n=794; BIP n=343, BD n=259, BM n=84).
RESULTS
There was significant difference for all red cell parameters between study groups (p<0.001). Age and sex may affect various erythrocyte parameters.
CONCLUSION
There are differences in erythrocyte parameters between schizophrenia, unipolar depression and bipolar disorder. Compared with schizophrenia, significantly higher percentage of patients with affective disorders has anemia or abnormal erythrocyte parameters. Positive correlations between age and MCV and RDW and negative correlation between other parameters and age were found in all study groups.