Association between high collagenase-3 expression levels and poor prognosis in patients with head and neck cancer
Association between high collagenase-3 expression levels and poor prognosis in patients with head and neck cancer
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DOI：
10.1002/hed.20322
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发表时间：
2006-03-01
影响因子：
2.9
通讯作者：
Grénman, R
中科院分区：
文献类型：
--
作者：
Luukkaa, M;Vihinen, P;Grénman, R
背景资料。头颈部鳞状细胞癌(HNSCC)是常见的癌症类型。手术加放射治疗(RT)的治疗能力通常高度依赖于诊断时的肿瘤分期。本研究的目的是确定HNSCC患者肿瘤特异性蛋白水解酶胶原酶-3(基质金属蛋白酶-13[MMP-13])的表达是否与生存参数有关。我们研究了81例单纯手术或联合放射治疗的I-IV期HNSCC患者肿瘤组织中基质金属蛋白酶-13的表达。我们发现一组患者的肿瘤中有高水平的基质金属蛋白酶-13表达(=90%的基质金属蛋白酶-13阳性的肿瘤细胞)与不良的预后相关(中位总生存期[OS]，11.8个月比19.6个月，p=.032)。此外，这一亚组的中位疾病特异性生存时间(DSS)显著缩短(13.8个月对40.7个月，p=.062)。当研究以治疗意图治疗的患者亚组时，在OS(13.8个月对24.6个月，p=.023)和DSS(p=.004)中发现了同样的关联。此外，在接受治疗的患者中，>；=90%的MMP-13阳性与肿瘤复发有关联的趋势(p=.078)。肿瘤大小或局部淋巴转移不能预测高表达的患者生存期短。这些结果表明，高水平的MMP-13表达与HNSCC的侵袭性有关，并可能对患者的预后评估有价值。(C)2005年威利期刊公司。
Background. Squamous call carcinoma of the head and neck (HNSCC) is a common cancer type. The ability for curative treatment with surgery and radiotherapy (RT) is usually highly dependent on tumor stage at the time of diagnosis.Methods. The purpose of this study was to determine whether the expression of a cancer-specific proteinase, collagenase-3 (matrix metalloproteinase-13 [MMP-13]), is associated with survival parameters in patients with HNSCC. We studied MMP-13 expression in tumors of 81 patients with stage I-IV HNSCC treated with surgery alone or in combination with radiotherapy.Results. We found a subgroup of patients with high MMP-13 expression level in their tumors (>= 90% MMP-13-positive tumor cells) associated with unfavorable prognosis (median overall survival [OS], 11.8 vs 19.6 months, p = .032). In addition, the median disease-specific survival (DSS) time was markedly reduced in this subgroup (13.8 months vs 40.7 months, p = .062). When the subgroup of patients treated with a curative intent was studied, the same association was found in OS (13.8 vs 24.6 months, p = .023) and DSS (p = .004). In addition, there was a trend for association between >= 90% MMP-13 positivity and a recurrent tumor (p = .078) in curatively treated patients.Conclusions. The short survival time associated with high MMP-13 expression levels could not be predicted by tumor size or local lymph node invasion. These results show that a high MMP-13 expression level is associated with aggressiveness of HNSCC and may have prognostic value in patient evaluation. (c) 2005 Wiley Periodicals, Inc.