DIFFERENTIAL VULNERABILITY OF CHOLINERGIC PROJECTIONS TO THE MEDIODORSAL NUCLEUS OF THE THALAMUS IN SENILE DEMENTIA OF ALZHEIMER TYPE AND PROGRESSIVE SUPRANUCLEAR PALSY
DIFFERENTIAL VULNERABILITY OF CHOLINERGIC PROJECTIONS TO THE MEDIODORSAL NUCLEUS OF THE THALAMUS IN SENILE DEMENTIA OF ALZHEIMER TYPE AND PROGRESSIVE SUPRANUCLEAR PALSY
复制标题
DOI：
10.1016/0306-4522(91)90197-v
复制
发表时间：
1991-01-01
期刊：
影响因子：
3.3
通讯作者：
AGID, Y
中科院分区：
文献类型：
--
作者：
BRANDEL, JP;HIRSCH, EC;AGID, Y
用乙酰胆碱酯酶组织化学和免疫组织化学方法研究了8例正常人、5例进行性核上性麻痹患者和4例阿尔茨海默型老年性痴呆患者的尸体组织中丘脑背内侧核的胆碱能神经支配。在对照组中，丘脑背内侧核的胆碱能神经支配分布不均匀，密集标记的补丁包围不太重染色的基质。在进行性核上性麻痹患者中，基质中胆碱乙酰转移酶阳性静脉曲张的密度降低了75%，斑片中降低了60%。背外侧被盖核胆碱乙酰转移酶阳性胞体减少84%，无名质减少33%。在阿尔茨海默型老年痴呆患者中，基质中胆碱乙酰转移酶阳性静脉曲张减少了34%，但斑片中减少了46%。胆碱乙酰转移酶标记的胞体在被盖背外侧核中无分布，而在无名质中则严重缺失（约80%），提示背内侧核基质的胆碱能神经支配主要来自被盖背外侧核和无名质的背内侧核斑片。进行性核上性麻痹和阿尔茨海默型老年性痴呆的基质和斑块的神经支配的差异性损失反过来可能会差异性地影响额皮质的背内侧核神经支配，从而导致不同的神经病理学。
The cholinergic innervation of the mediodorsal nucleus of the thalamus, which is thought to originate primarily in the laterodorsal tegmental nucleus and the substantia innominata, was studied by acetylcholinesterase histochemistry and immunohistochemistry with a polyclonal antiserum against human choline acetyltransferase on autopsy tissue from eight control subjects, five patients with progressive supranuclear palsy and four patients with senile dementia of Alzheimer type. In controls, cholinergic innervation of the mediodorsal nucleus of the thalamus was distributed heterogeneously in densely labelled patches surrounded by less heavily stained matrix. In patients with progressive supranuclear palsy, the density of choline acetyltransferase-positive varicosities decreased by 75% in the matrix and 60% in the patches. The number of choline acetyltransferase-positive cell bodies decreased by 84% in the laterodorsal tegmental nucleus, but more moderately (-33%) in the substantia innominata. In patients with senile dementia of Alzheimer type, choline acetyltransferase-positive varicosities decreased by 34% in the matrix, but 46% in the patches. Choline acetyltransferase-labelled cell bodies were spared in the laterodorsal tegmental nucleus, whereas severe loss (-80%) was observed in the substantia innominata.These results suggest that cholinergic innervation of mediodorsal nucleus matrix derives mainly from the laterodorsal tegmental nucleus and mediodorsal nucleus patches from the substantia innominata. Differential loss of innervation to the matrix and patches in progressive supranuclear palsy and senile dementia of Alzheimer type may in turn differentially affect mediodorsal nucleus innervation of the frontal cortex, resulting in dissimilar symptomatologies.