Concerted evolution and RAPping in mitochondrial VNTRs and the molecular geography of cricket populations.
Concerted evolution and RAPping in mitochondrial VNTRs and the molecular geography of cricket populations.
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线粒体 VNTR 的协同进化和 RAPping 以及蟋蟀种群的分子地理学。
DOI：
10.1007/978-3-0348-7527-1_13
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Rand,DM
中科院分区：
文献类型：
--
作者：
Rand,DM
近年来，许多动物的线粒体DNA控制区都存在数目可变的串联重复序列（VNTR）。为了表征的VNTR系统的核苷酸多态性，该区域进行了测序的个人从两个物种的蟋蟀（genusGryllus）收集在大陆的地方和岛屿的地方在每个物种。这些数据揭示了一个明确的协同进化模式：个体和种群内重复序列之间的同质性，但不同种群的串联阵列之间以及物种之间的异质性。阵列内的核苷酸多态性的模式显示部分均质化的几个实例，其中衍生的核苷酸没有扫过阵列中的所有重复。这些都是“当场被抓”的协同进化的例子。额外的重复相关多态性（RAP）揭示了重复单元插入和缺失的分子基础，并与VNTRs的协同进化，提供了物种内和物种间岛屿和大陆种群的地理分辨率。VNTR内的多态性也提供了一个简单的系统，在其中检查突变和漂移的平衡，并提供了一个独特的观点，在分子进化的模式和过程中的基因组和生物现象的历史。
In recent years, many animal species have been shown to exhibit a variable number of tandem repeats (VNTR) in the control region of their mitochondrial DNA. To characterize the nucleotide polymorphism of a VNTR system, this region was sequenced in individuals from two species of crickets (genusGryllus) collected at a mainland locality and an island locality within each species. The data reveal a clear pattern of concerted evolution: homogeneity among repeats within individuals and populations, but heterogeneity among the tandem arrays from divergent populations, and between species. The patterns of nucleotide polymorphisms within the arrays show several instances of partial homogenization where derived nucleotides have not swept through all the repeats in the array. These serve as examples of concerted evolution “caught in the act”. Additional repeat associated polymorphisms (RAPs) shed light on the molecular basis of the insertion and deletion of repeat units and, with the concerted evolution of VNTRs, provide phylogeographic resolution of island and mainland populations within and between species. The polymorphisms within VNTRs also provide a simple system in which to examine the balance of mutation and drift and offer a unique view of the histories of genomic and organismal phenomena in the patterns and processes of molecular evolution.