The Copenhagen High-Risk Project, 1962-86.
The Copenhagen High-Risk Project, 1962-86.
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哥本哈根高风险项目，1962-86。
DOI：
10.1093/schbul/13.3.485
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发表时间：
1987
影响因子：
6.6
通讯作者：
Schulsinger,F
中科院分区：
文献类型：
--
作者：
Mednick,SA;Parnas,J;Schulsinger,F
自 1962 年以来，我们对 207 名精神分裂症高危儿童以及 104 名对照儿童进行了抽样调查。对于这些人来说，以下因素及其相互作用与精神分裂症崩溃的风险增加有关：（1）更大的精神分裂症家庭背景，（2）围产期创伤，以及（3）不稳定的养育和公共机构儿童保育。围产期困难与成年脑室周围萎缩呈正相关。随后的研究结果初步表明，精神分裂症的部分神经异常可能是由于胎儿发育中期发生的破坏造成的。
Since 1962 we have followd a sample of 207 children at high risk for schizophrenia as well as 104 control children. For these individuals, the following factors and their interaction are related to an increased risk for schizophrenic breakdown: (1) greater schizophrenia family backgrounds, (2) perinatal trauma, and (3) unstable parenting and public institutional child care. The perinatal difficulties are positively related to adult periventricular atrophy. Results of a subsequent study tentatively suggest that part of the neurological deviance in schizophrenia may be produced by disruption occurring in the second trimester of fetal development.