Decreased Blood-Brain Barrier Permeability to Sodium in Early Experimental Diabetes
Decreased Blood-Brain Barrier Permeability to Sodium in Early Experimental Diabetes
复制标题
早期实验性糖尿病中血脑屏障对钠的渗透性降低
DOI：
10.2337/diab.35.12.1371
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发表时间：
1986
期刊：
影响因子：
7.7
通讯作者：
O. Paulson
中科院分区：
文献类型：
--
作者：
G. Knudsen;J. Jakobsen;M. Juhler;O. Paulson
用链脲佐菌素诱导的糖尿病大鼠2wk后，观察血脑屏障对24Na+36CI-−和[~3H]蔗糖的通透性。糖尿病大鼠额叶皮质Na+的通透性表面积乘积(PS)为5.4±0.6(105cm3g−1·S−1；±SD)，对照组为7.1±1.7。枕叶皮质分别为7.6±1.5和9.9±1.6。相比之下，血脑屏障对氯−和蔗糖的通透性没有变化。我们得出结论，实验性糖尿病患者血脑屏障对Na+的通透性存在选择性改变，与脑毛细血管表面积的变化无关。
Blood-brain barrier (BBB) permeability to 24Na+ 36CI−, and [3H] sucrose was studied in rats after 2 wk of streptozocin-induced diabetes. The PS (permeabilitysurface area product) for Na+ in the cortex of the frontal lobes was 5.4 ± 0.6 (105 cm3 g−1 · s−1; ± SD) in diabetic rats compared with 7.1 ± 1.7 in control rats. In the occipital cortex, the values were 7.6 ± 1.5 and 9.9 ± 1.6, respectively. In contrast, BBB permeability to Cl− and sucrose remained unchanged. We conclude that a selective alteration in BBB permeability to Na+ unrelated to changes in brain capillary surface area is present in experimental diabetes.