Cytotoxic constituents of ethyl acetate fraction from Dianthus superbus
Cytotoxic constituents of ethyl acetate fraction from Dianthus superbus
复制标题
石竹乙酸乙酯部分的细胞毒性成分。
DOI：
10.1080/14786419.2012.763127
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发表时间：
2013-09-01
影响因子：
2.2
通讯作者：
Yu, Jianqing
中科院分区：
文献类型：
--
作者：
Ding, Chengli;Zhang, Wu;Yu, Jianqing
在前人的研究中发现石竹的乙酸乙酯部分（ees - ds）对癌细胞具有细胞毒活性。为了研究细胞毒性成分，采用生物测定法从ees - ds中分离化合物。得到两种双氰胺（1和2）、三种黄酮类化合物（3-5）、两种香豆素（6和7）和三种其他化合物（8-10）。通过光谱分析鉴定了分离化合物的结构。评价化合物对HepG2细胞的细胞毒性。化合物1的细胞毒性最强，化合物10、4、3和5的细胞毒性中等。
The ethyl acetate fraction (EE-DS) from Dianthus superbus was found to possess the cytotoxic activity against cancer cells in previous study. To investigate cytotoxic constituents, the bioassay-guided isolation of compounds from EE-DS was performed. Two dianthramides (1 and 2), three flavonoids (3-5), two coumarins (6 and 7) and three other compounds (8-10) were obtained. Structures of isolated compounds were identified by spectroscopic analysis. Cytotoxicity of the compounds against HepG2 cells was evaluated. Compound 1 showed the strongest cytotoxicity, compounds 10, 4, 3 and 5 had moderate cytotoxicity.