Fabrication of collagen membranes with different intrafibrillar mineralization degree as a potential use for GBR.
Fabrication of collagen membranes with different intrafibrillar mineralization degree as a potential use for GBR.
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DOI：
10.1016/j.msec.2019.109959
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发表时间：
2019-11
期刊：
影响因子：
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通讯作者：
Jing Wang;Y. Qu;Chaoqun Chen;Jian Sun;H. Pan;C. Shao;R. Tang;Xinhua Gu
中科院分区：
文献类型：
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作者：
Jing Wang;Y. Qu;Chaoqun Chen;Jian Sun;H. Pan;C. Shao;R. Tang;Xinhua Gu
生物矿化在牙本质和骨组织修复中的作用已被广泛研究。在体外，生物矿化可以通过聚合物诱导的液体前体（PILP）过程来刺激。在骨容量不足的情况下，利用屏障膜和骨替代材料引导骨再生被广泛应用于种植外科。在此，我们应用了一种同源的PILP工艺来制备具有不同矿化程度的胶原膜，并测试了它们的性能。结果表明，制备的生物矿化膜具有良好的生物相容性，具有较高的应力强度，可促进MC3T3-e1细胞增殖。这表明该膜具有潜在的应用于引导骨再生的潜力，其中含有较高矿化程度的膜可获得最佳效果。
The process of biomineralization in dentin and bone tissue repair has been extensively studied. In vitro, biomineralization can be stimulated via a polymer-induced liquid precursor (PILP) process. Guided bone regeneration using a barrier membrane and bone substitute materials is widely used in implantology in cases where there is insufficient bone volume. Herein, we applied a homologous PILP processes to fabricate collagen films with a varying degree of mineralization and tested their performance. The results showed that the prepared biomineralized membranes are biocompatible, have a high stress strength and can promote MC3T3-e1 cell proliferation. This indicated that the membranes can be potentially applied in guided bone regeneration, with membranes containing a higher degree of mineralization achieving the best results.