The functional neuroanatomy of odor evoked autobiographical memories cued by odors and words
The functional neuroanatomy of odor evoked autobiographical memories cued by odors and words
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DOI：
10.1016/j.neuropsychologia.2012.10.023
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发表时间：
2013-01-01
期刊：
影响因子：
2.6
通讯作者：
Larsson, Maria
中科院分区：
文献类型：
--
作者：
Arshamian, Artin;Iannilli, Emilia;Larsson, Maria
行为学证据表明，气味诱发的自传体记忆比其他方式诱发的自传体记忆更古老、更情绪化、更少被思考，并且具有更强的时间旅行特征。本研究的主要目的是探讨气味作为检索线索的功能所诱发的AMs的神经关联。参与者被筛选特定的oeam，然后在fMRI范式中呈现气味线索及其言语参照物。由于在两种线索格式（气味和单词）中检索到相同的OEAM，因此研究了潜在线索依赖的大脑激活。总体结果表明，气味和单词提示的脑电刺激激活了与自传体信息回忆相关的典型区域。虽然没有出现气味，但言语提示的oeam激活了与嗅觉感知相关的区域（例如，梨状皮质）。然而，相对于单词提示，oeam的气味提示导致MTL区域（如副海马体）和与视觉生动相关的区域（如枕回和楔前叶）更活跃。此外，气味线索激活了与情绪处理相关的区域，如边缘和颞极区域。相比之下，与气味线索相比，文字线索调动了更广泛的双侧前额叶活动。海马的活动不随记忆距离的不同而变化，但对前十年和后十年的oeam的回忆显示右侧OFC有特定的激活，而后十年则反映了左侧额下回更高的激活。(C) 2012 Elsevier Ltd.版权所有。
Behavioral evidence indicates that odor evoked autobiographical memories (OEAMs) are older, more emotional, less thought of and induce stronger time traveling characteristics than autobiographical memories (AMs) evoked by other modalities. The main aim of this study was to explore the neural correlates of AMs evoked by odors as a function of retrieval cue. Participants were screened for specific OEAMs and later presented with the odor cue and its verbal referent in an fMRI paradigm. Because the same OEAM was retrieved across both cue formats (odor and word), potential cue dependent brain activations were investigated. The overall results showed that odor and word cued OEAMs activated regions typically associated with recollection of autobiographical information. Although no odors were presented, a verbal cuing of the OEAMs activated areas associated with olfactory perception (e.g., piriform cortex). However, relative to word cuing, an odor cuing of OEAMs resulted in more activity in MTL regions such as the parahippocampus, and areas involved in visual vividness (e.g., occipital gyrus and precuneus). Furthermore, odor cues activated areas related to emotional processing, such as limbic and tempopolar regions significantly more. In contrast, word cues relative to odor cues recruited a more widespread and bilateral prefrontal activity. Hippocampus activity did not vary as function of the remoteness of the memory, but recollection of OEAMs from the 1st vs the 2nd decade of life showed specific activation in the right OFC, whereas the 2nd reflected a higher activation in the left inferior frontal gyrus. (C) 2012 Elsevier Ltd. All rights reserved.