Dementia and adult-onset unprovoked seizures
Dementia and adult-onset unprovoked seizures
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DOI：
10.1212/wnl.46.3.727
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发表时间：
1996-03-01
期刊：
影响因子：
9.9
通讯作者：
Rocca, WA
中科院分区：
文献类型：
--
作者：
Hesdorffer, DC;Hauser, WA;Rocca, WA
目的：我们检验了痴呆增加成年人无缘无故癫痫发作风险的假设。部分性发作和全身性发作同时或分别考虑。此外，我们探讨了增加的风险是否仅限于阿尔茨海默病（AD），如前所述。设计图：这项基于人群的病例对照研究的受试者为145例年龄≥ 55岁的首次无端癫痫发作（既往无卒中、CNS感染、脑肿瘤、头部创伤、精神发育迟滞或脑瘫），290例对照组在年龄、性别和医疗随访持续时间方面与病例匹配。使用罗切斯特流行病学项目的记录链接系统，我们获得了两个病例和匹配的对照组在无端癫痫发作前痴呆的信息。如果受试者符合DSM-III中的特定标准，则将其归类为痴呆。AD与其他痴呆不同。结果如下：在罗切斯特，当控制年龄、性别和医疗随访时间时，AD和其他痴呆的诊断与无端癫痫发作的风险增加至少6倍相关。风险没有差异。比较全身性癫痫发作和部分性癫痫发作。结论：在没有其他神经损伤的情况下，AD和其他痴呆的风险增加。全身性和部分性无缘无故的癫痫发作
Objective: We tested the hypothesis that dementia increases the risk of unprovoked seizure among adults. Partial- and generalized-onset seizures were considered together and separately. Additionally, we explored whether the increased risk was restricted to Alzheimer's disease (AD), as previously shown. Design: Subjects in this population-based case-control study were 145 incident cases of first unprovoked seizure (without prior stroke, CNS infection, brain tumor, head trauma, mental retardation, or cerebral palsy) aged 55 years or older and 290 controls matched to cases on age, gender, and duration of medical follow-up. Using the records-linkage system of the Rochester Epidemiology Project, we obtained, for both cases and matched controls, information on dementia prior to onset of unprovoked seizure. Subjects were classified as having dementia if they met ad hoc criteria equivalent to those in the DSM-III. AD was distinguished from other dementias. Results: Both a diagnosis of AD and a diagnosis of other dementia were associated with at least a six-fold increased risk of unprovoked seizure when controlling for age, sex, and length of medical follow-up in Rochester. There was no difference in risk. when comparing generalized-onset seizures with partial-onset seizures. Conclusions: In the absence of other prior neurologic insult, both AD and other dementias increase the risk. of generalized- and partial-onset unprovoked seizures.