Fetal growth indicators and perfluorinated chemicals: A study in the Danish National Birth Cohort
Fetal growth indicators and perfluorinated chemicals: A study in the Danish National Birth Cohort
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DOI：
10.1093/aje/kwn095
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发表时间：
2008-07-01
影响因子：
5
通讯作者：
Olsen, Jorn
中科院分区：
文献类型：
--
作者：
Fei, Chunyuan;McLaughlin, Joseph K.;Olsen, Jorn
全氟辛烷酸（PFOA）和全氟辛烷磺酸（PFOS）是广泛存在的持久性有机污染物，与许多怀孕人群预期的出生体重减少有关。作者从丹麦国家出生队列（1996-2002）中随机选择了1400名孕妇和她们的新生儿来调查这些化合物是否会减少器官生长。在妊娠早期采集的母体血液样本中测量全氟辛烷磺酸和全氟辛酸。胎盘重量、出生长度、头部和腹部围在出生后不久由训练有素的助产士或护士测量。妊娠早期母体PFOA水平与较小的腹围和出生长度有关。PFOA浓度每增加ng/ml，出生体长减少0.069 cm(95%可信区间：0.024,0.113)，腹围减少0.059 cm（95%可信区间：0.012,0.106）。PFOA与胎盘重量、头围呈负相关，与新生儿体重指数呈正相关，但均无统计学意义。母亲的全氟辛烷磺酸水平与五项胎儿生长指标中的任何一项都无关。这些发现表明，胎儿在器官发育过程中暴露于全氟辛烷磺酸而不是全氟辛烷磺酸可能会影响器官和骨骼的生长。
Perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS) are widespread persistent organic pollutants that have been associated with reduced birth weight at doses expected in many pregnant populations. The authors randomly selected 1,400 pregnant women and their newborns from the Danish National Birth Cohort (1996-2002) to investigate whether these compounds reduce organ growth. PFOS and PFOA were measured in maternal blood samples taken early in pregnancy. Placental weight, birth length, and head and abdominal circumferences were measured shortly after birth by trained midwives or nurses. Maternal PFOA levels in early pregnancy were associated with smaller abdominal circumference and birth length. For each ng/ml increase in PFOA, birth length decreased by 0.069 cm (95% confidence interval: 0.024, 0.113) and abdominal circumference decreased by 0.059 cm (95% confidence interval: 0.012, 0.106). An inverse association was also observed between PFOA and placental weight and head circumference, and a positive association was observed with newborn ponderal index, but none of these associations was statistically significant. Maternal PFOS levels were not associated with any of the five fetal growth indicators. These findings suggest that fetal exposure to PFOA but not PFOS during organ development may affect the growth of organs and the skeleton.