Effect of vitamin B12-deficiency on testicular tissue in rats fed by pair-feeding.
Effect of vitamin B12-deficiency on testicular tissue in rats fed by pair-feeding.
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维生素 B12 缺乏对配对喂养大鼠睾丸组织的影响。
DOI：
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
A. Maekawa
中科院分区：
文献类型：
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作者：
T. Kawata;A. Tamiki;A. Tashiro;K. Suga;S. Kamioka;K. Yamada;M. Wada;N. Tanaka;T. Tadokoro;A. Maekawa
通过对饲喂缺乏 B12 的大豆蛋白饲料 100 天的大鼠进行形态学观察，研究维生素 B12 (B12) 缺乏对睾丸组织的影响。睾丸维生素 B12 含量因缺乏而明显降低。与配对喂养的对照大鼠相比，睾丸重量及其相对重量（每100克体重的重量）也显着下降。虽然由于维生素 B12 缺乏而导致的睾丸维生素 B12 含量的减少可以通过服用氰钴胺素 (CN-B12) 得到补偿，但在短期服用 CN-B12 的情况下，并未观察到睾丸重量和相对睾丸重量的减少得到缓解。对缺乏 B12 的大鼠睾丸组织的形态学观察显示，生精小管萎缩，精子和精细胞发育不全，而随意喂养的对照大鼠和配对喂养的对照大鼠的睾丸结果均正常。通过给予CN-B12，显示出精子发生的生精小管的减少有减轻的趋势。上述结果表明，睾丸组织的形态变化与维生素 B12 缺乏有关。
The effect of vitamin B12 (B12)-deficiency on testicular tissue was investigated through morphological observations of the rats which had been fed on a B12-deficient soybean protein diet by pair-feeding for 100 days. Testicular B12 content was depressed distinctly by the deficiency. Testes weight and their relative weight (weight per 100 g body weight) as well, decreased significantly as compared with those of pair-feeding control rats. Although the decrease in the testicular B12 content due to B12-deficiency was compensated by the administration of cyanocobalamin (CN-B12), alleviation of the decrease in testes weight and relative testes weight was not observed under the condition of the short-term CN-B12 administration. Morphological observations of the testicular tissue in B12-deficient rats revealed atrophy of the seminiferous tubules and aplasia of sperms and spermatids, while testicular findings in both ad libitum-feeding control rats and pair-feeding control rats were normal. There was a tendency for the decrease in seminiferous tubules showing spermatogenesis to be alleviated by administration of CN-B12. The above results indicate that the morphological changes in the testicular tissue are ascribable to B12-deficiency.