Linear and nonlinear elastic modulus imaging: an application to breast cancer diagnosis.
Linear and nonlinear elastic modulus imaging: an application to breast cancer diagnosis.
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DOI：
10.1109/tmi.2012.2201497
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发表时间：
2012-08
影响因子：
10.6
通讯作者：
Oberai AA
中科院分区：
文献类型：
--
作者：
Goenezen S;Dord JF;Sink Z;Barbone PE;Jiang J;Hall TJ;Oberai AA
我们重建了10例良性（5例）和恶性（5例）肿瘤患者的线性和非线性弹性参数的体内空间分布。乳腺组织的力学行为由一个修正的Veronda-Westmann模型表示，该模型具有一个线性和一个非线性弹性参数。这些弹性参数的空间分布通过求解感兴趣区域（ROI）内的逆问题来确定。这个反问题的解决方案需要在小应变和大应变的位移场的知识。使用徒手超声应变成像技术测量位移场，其中，线性阵列超声换能器被定位在乳房上，并且当组织用换能器缓慢变形时，在ROI内记录射频回波信号。增量位移场确定从连续的射频帧通过采用互相关技术。主观选择感兴趣的矩形区域以获得低噪声位移估计值，因此变量范围为346至849.6 mm 2。据观察，恶性肿瘤以比良性肿瘤更快的速率扩散，并且基于该标准，十分之九的肿瘤被正确地分类为良性或恶性。
We reconstruct the in vivo spatial distribution of linear and nonlinear elastic parameters in ten patients with benign (five) and malignant (five) tumors. The mechanical behavior of breast tissue is represented by a modified Veronda–Westmann model with one linear and one nonlinear elastic parameter. The spatial distribution of these elastic parameters is determined by solving an inverse problem within the region of interest (ROI). This inverse problem solution requires the knowledge of the displacement fields at small and large strains. The displacement fields are measured using a free-hand ultrasound strain imaging technique wherein, a linear array ultrasound transducer is positioned on the breast and radio frequency echo signals are recorded within the ROI while the tissue is slowly deformed with the transducer. Incremental displacement fields are determined from successive radio-frequency frames by employing cross-correlation techniques. The rectangular regions of interest were subjectively selected to obtain low noise displacement estimates and therefore were variables that ranged from 346 to 849.6 mm2. It is observed that malignant tumors stiffen at a faster rate than benign tumors and based on this criterion nine out of ten tumors were correctly classified as being either benign or malignant.