Total Synthesis of the Analgesic Conotoxin MrVIB through Selenocysteine-Assisted Folding
Total Synthesis of the Analgesic Conotoxin MrVIB through Selenocysteine-Assisted Folding
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DOI：
10.1002/anie.201101642
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发表时间：
2011-01-01
影响因子：
16.6
通讯作者：
Alewood, Paul F.
中科院分区：
文献类型：
--
作者：
de Araujo, Aline Dantas;Callaghan, Brid;Alewood, Paul F.
折叠问题：硒半胱氨酸（Sec）残基用于驱动螺毒素MrVIB的折叠，这是一种以前“不可折叠”的具有治疗潜力的微型蛋白（见图）。这种简单的策略通常会促进具有多个二硫键的肽和蛋白质的折叠。
Secs for your folding problems: Selenocysteine (Sec) residues were used to drive the folding of conotoxin MrVIB, a previously "unfoldable" miniprotein with therapeutic potential (see picture). This simple strategy should generally facilitate the folding of peptides and proteins with multiple disulfide bonds.