Placebo response rates in psychotic and nonpsychotic depression.
Placebo response rates in psychotic and nonpsychotic depression.
复制标题
精神病性和非精神病性抑郁症的安慰剂反应率。
DOI：
10.1016/0165-0327(88)90067-5
复制
发表时间：
1988
影响因子：
6.6
通讯作者：
Kupfer,DJ
中科院分区：
文献类型：
--
作者：
Spiker,DG;Kupfer,DJ
作者重新分析了两项早期研究的数据，这些研究采用双盲安慰剂对照的形式来研究阿米替林的疗效。使用14天的无药物“洗脱”期，他们发现精神病性抑郁症患者的安慰剂反应率为0%，非精神病性抑郁症患者为13.3%。阿米替林治疗精神病性（P <0.05）和非精神病性（P <0.05）抑郁症患者的疗效均显著优于安慰剂（上级）。
The authors reanalyzed data from two earlier studies that used double-blind placebo-controlled formats to study the efficacy of amitriptyline. Using a 14-day drug-free ‘wash-out’ period, they found that the placebo response rates were 0% for psychotic depressives and 13.3% for nonpsychotic depressives. Amitriptyline was significantly superior to placebo for both psychotic (P⩽ 0.05) and nonpsychotic (P⩽ 0.05) depressed patients.