Anticancer photodynamic and non-photodynamic effects of pterin derivatives on a pancreatic cancer cell line
Anticancer photodynamic and non-photodynamic effects of pterin derivatives on a pancreatic cancer cell line
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DOI：
10.1254/jphs.08002sc
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发表时间：
2008-06-01
影响因子：
3.5
通讯作者：
Sasada, Masataka
中科院分区：
文献类型：
--
作者：
Miyoshi, Takashi;Arai, Toshlyuki;Sasada, Masataka
为评价2-（N，N-二甲氨基亚甲基氨基）-6-甲酰基-3-新戊酰基蝶啶-4-酮（DFP）和2-（N，N-二甲氨基亚甲基氨基）-3-新戊酰基蝶啶-4-酮（DP）作为抗癌药物的可行性，研究了它们对胰腺癌细胞株Panc-1的光动力学和非光动力学效应。对于光动力学效应，UV-A照射后48 h的细胞死亡在DP预加载的细胞中比DFP更突出。当细胞简单地孵育96小时，没有照射，DFP诱导细胞死亡，而DP抑制细胞增殖。此外，DP比DFP更易溶于水。这些结果共同表明，DP作为抗癌药物比DFP更可行。
To evaluate the feasibility of two kinds of pterin derivatives, 2-(NN-dimethylaminoinethyleneamirio)-6-formyl-3-pivaloylpteridin-4-one (DFP) and 2-(N,N-dimethylaminomethyleneamino)-3-pivaloylpteridin-4-one (DP), as anticancer drugs, their photodynamic and non-photodynamic effects on pancreatic cancer cell line Panc-1 cells were examined. For photodynamic effects, cell death 48 h after UV-A irradiation was more prominent in cells preloaded with DP than DFP. When cells were simply incubated for 96 h without irradiation, DFP induced cell death, while DP suppressed cell proliferation. Furthermore, DP was much more soluble in water than DFP. These findings collectively indicated that DP is more feasible as an anticancer drug than DFP.