Experience-Driven Rate Modulation is Reinstated During Hippocampal Replay
Experience-Driven Rate Modulation is Reinstated During Hippocampal Replay
复制标题
海马重放期间恢复经验驱动的速率调节
DOI：
10.1101/2021.07.15.452506
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Tirole M
中科院分区：
文献类型：
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作者：
Tirole M
重放，神经元整体内的顺序再激活，是一种被假设为驱动记忆处理的中央海马机制。虽然海马位置细胞使用速率和位置表征来编码行为事件，但重放在很大程度上仅由后者定义-基于相邻位置场的顺序活动的保真度。在这里，我们表明，背侧CA 1的地方细胞在大鼠可以调节其放电率之间的两个不同的情况下重放事件。这种依赖经验的现象反映了在行为过程中观察到的相同的速率调制模式，并且可以独立于重放序列内的位置信息来区分上下文。我们的研究结果揭示了存在两个互补的神经表征可用于记忆过程。
Replay, the sequential reactivation within a neuronal ensemble, is a central hippocampal mechanism postulated to drive memory processing. While both rate and place representations are used by hippocampal place cells to encode behavioral episodes, replay has been largely defined by only the latter–based on the fidelity of sequential activity across neighboring place fields. Here, we show that dorsal CA1 place cells in rats can modulate their firing rate between replay events of two different contexts. This experience-dependent phenomenon mirrors the same pattern of rate modulation observed during behavior and can be used independently from place information within replay sequences to discriminate between contexts. Our results reveal the existence of two complementary neural representations available for memory processes.