DECREASED MOLECULAR CHAPERONE PROPERTY OF ALPHA-CRYSTALLINS DUE TO POSTTRANSLATIONAL MODIFICATIONS
DECREASED MOLECULAR CHAPERONE PROPERTY OF ALPHA-CRYSTALLINS DUE TO POSTTRANSLATIONAL MODIFICATIONS
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DOI:
10.1006/bbrc.1995.1391
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发表时间:
1995-03-17
影响因子:
3.1
通讯作者:
ABRAHAM, EC
中科院分区:
文献类型:
--
作者:
CHERIAN, M;ABRAHAM, EC
We studied the effect of oxidation, mixed disulfide formation and glycation of alpha-crystallins on their molecular chaperone property. The ability of alpha-crystallins to protect heat-induced denaturation and aggregation of beta L-crystallin was significantly diminished by these modifications. alpha-Crystallin from senile human lenses also showed significant loss of chaperone-like property. Age-dependent increase in posttranslationally modified alpha-crystallins is the likely cause for this change. (C) 1995 Academic Press. Inc.