Manual and semiautomated measurement of cerebellar subregions on MR images
Manual and semiautomated measurement of cerebellar subregions on MR images
复制标题
DOI：
10.1006/nimg.2002.1207
复制
发表时间：
2002-09-01
期刊：
影响因子：
5.7
通讯作者：
Andreasen, NC
中科院分区：
文献类型：
--
作者：
Pierson, R;Corson, PW;Andreasen, NC
以往的结构和功能成像研究表明，皮质-小脑-丘脑-皮质回路在精神分裂症中功能障碍。小脑亚区的准确识别和体积测量对于评估小脑在健康和疾病状态中的作用至关重要。使用引导迹线在MR图像上进行小脑的手动包裹。引导迹线识别了几个平面中的相关裂缝和边界，并使用其与主要迹线平面的交叉点来保持分割过程中的一致性和准确性。小脑分为左右前叶、上级后叶、下后叶和髓体。对最后的痕迹进行了系统的审查，以确保其准确性。一个人工神经网络的训练，使用一种新的地标扭曲的方法，以帮助占结构的大小和位置的广泛变化。手动追踪的肺叶重叠（交叉/联合）范围为0.78 - 0.85，组内相关性（r（2））范围为0.82 - 0.94。在半自动方法与手动方法的比较中，重叠范围为0.83至0.88，组内相关性范围为0.92至0.97。对于两个评分者使用半自动方法重叠范围从0.83至0.88和组内相关性范围从0.97至0.99。半自动方法建立在手动方法的基础上，可以在一小部分时间内产生更可靠的结果，从而可以对大量受试者进行有效的测量。(C)2002年爱思唯尔科学（美国）。
Previous structural and functional imaging studies suggest that the corticocerebellar-thalamic-cortical circuit is dysfunctional in schizophrenia. Accurate identification and volumetric measurement of cerebellar subregions are essential to the assessment of the cerebellum's role in healthy and disease states. Manual parcellation of the cerebellum on MR images was performed with the use of guide traces. Guide traces identified relevant fissures and borders in several planes, and their intersections with the primary tracing plane were used to maintain consistency and accuracy during the parcellation. The cerebellum was parcellated into right and left anterior lobes, superior posterior lobes, inferior posterior lobes, and corpus medullare. A systematic review of the final traces ensured their accuracy. An artificial neural network was trained using a novel landmark-warped method to help account for wide variability in structure size and location. Overlaps of the manually traced lobes (intersection/union) ranged from 0.78 to 0.85 and intraclass correlations (r(2)) ranged from 0.82 to 0.94. In a comparison of the semiautomated method with the manual method overlaps ranged from 0.83 to 0.88 and intraclass correlations ranged from 0.92 to 0.97. For two raters using the semiautomated method overlaps ranged from 0.83 to 0.88 and intraclass correlations ranged from 0.97 to 0.99. The semiautomated method was built on the groundwork of the manual method to produce more reliable results in a fraction of the time, making valid measurements possible on a large number of subjects. (C) 2002 Elsevier Science (USA).